Saberi Sogol, Hakimiha Neda, Alaeddini Mojgan, Etemad-Moghadam Shahroo, Roudbari Payam, Shahabi Sima
Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2022 Nov 20;13:e49. doi: 10.34172/jlms.2022.49. eCollection 2022.
Due to the increasing prevalence and high mortality rate of oral squamous cell carcinoma (OSCC) and problems with its routine treatments, more recent modalities like photodynamic therapy (PDT) have been developed. PDT effectively destroys tumor cells with minimum side effects. Research on effects of PDT may be helpful in determining the molecular mechanisms responsible for its effectiveness and can lead to the development of more efficient techniques. The aim of this study was to review the use of PDT in OSCC among studies. A literature search for English articles on PDT in OSCC was performed in PubMed, Scopus, Google Scholar, and Web of Science. Data were extracted based on the inclusion/exclusion criteria, which were detailed using the PICO framework: all eligible studies evaluating the effects of PDT on the viability of OSCC compared to controls without PDT were included. Forty-one out of 567 studies were selected. The tongue was the most common OSCC site, 5-aminolevulinic acid was the most used photosensitizer (PS), cell viability/toxicity and apoptosis were the most evaluated outcomes, and lasers with wavelengths of 600-700 nm were the most common light sources and wavelengths respectively. PDT showed promising effects on reducing the viability of OSCC cells. Cell lines from various sources or even those originating from the same location sometimes responded differently to the same protocol. Considering the favorable results obtained from natural PSs and regarding their additional health-promoting properties, their use in future investigations with different cell lines and light specifications is recommended.
由于口腔鳞状细胞癌（OSCC）的患病率不断上升、死亡率高以及其常规治疗存在问题，近年来已开发出如光动力疗法（PDT）等新的治疗方式。PDT能以最小的副作用有效破坏肿瘤细胞。对PDT作用的研究可能有助于确定其有效性的分子机制，并能推动更高效技术的发展。本研究的目的是回顾PDT在OSCC研究中的应用。在PubMed、Scopus、谷歌学术和科学网中检索关于OSCC中PDT的英文文章。根据纳入/排除标准提取数据，这些标准使用PICO框架详细说明：纳入所有评估PDT对OSCC细胞活力影响并与未接受PDT的对照组进行比较的合格研究。在567项研究中筛选出41项。舌是最常见的OSCC发病部位，5-氨基酮戊酸是最常用的光敏剂（PS），细胞活力/毒性和细胞凋亡是评估最多的结果，波长为600-700nm的激光分别是最常见的光源和波长。PDT在降低OSCC细胞活力方面显示出有前景的效果。来自不同来源甚至同一部位的细胞系有时对相同方案的反应不同。考虑到从天然PSs获得的良好结果及其额外的促进健康特性，建议在未来对不同细胞系和光照规格的研究中使用它们。
