Dubbert Justin, Höing Alexander, Graupner Nadine, Rajter Ľubomír, Dunthorn Micah, Knauer Shirley K, Galstyan Anzhela, Rizzo Fabio, Voskuhl Jens
Faculty of Chemistry (Organic Chemistry), Center of Medical Biotechnology (ZMB) and, Center for NanoIntegration (CENIDE), University of Duisburg-Essen, Universitätsstrasse 7, 45117, Essen, Germany.
Institute for Molecular Biology II, Center for Medical Biotechnology (ZMB), University of Duisburg-Essen, Universitätsstrasse 5, 45117, Essen, Germany.
Chemistry. 2023 Jul 6;29(38):e202300334. doi: 10.1002/chem.202300334. Epub 2023 May 15.
A library of eight different cationic emitters with emission properties in solution and in solid-state (solution and solid-state emitters - SSSE) is presented. These compounds, bearing either ammonium or pyridinium groups, have been investigated regarding their photophysical properties as well as their potential application in biological imaging. Besides high quantum yields as well as a high degree of stability during the imaging process, it was additionally revealed that a broad range of biological targets can be addressed, such as different bacterial strains, human cells as well as protists. The reported SSSE approach employing the mentioned robust emitters for biological imaging, will contribute to a rapid and facile way to design and apply affordable emitters with outstanding properties. Additionally, these emitters will overcome the drawbacks of classical luminophores and agents featuring well-known aggregation-induced emission (AIE) or aggregation-caused quenching (ACQ) properties.
本文展示了一个包含八种不同阳离子发射体的库,这些发射体在溶液和固态中均具有发射特性(溶液和固态发射体 - SSSE)。这些带有铵基或吡啶鎓基的化合物,已对其光物理性质以及在生物成像中的潜在应用进行了研究。除了具有高量子产率以及在成像过程中具有高度稳定性外,还额外发现可以靶向广泛的生物靶点,例如不同的细菌菌株、人类细胞以及原生生物。所报道的使用上述稳健发射体进行生物成像的SSSE方法,将有助于以快速简便的方式设计和应用具有出色性能的经济实惠的发射体。此外,这些发射体将克服具有众所周知的聚集诱导发光(AIE)或聚集导致猝灭(ACQ)特性的经典发光体和试剂的缺点。