Sleiman Sue, Bacha Feyrous, Handelsman David J
Clinical Andrology Laboratory, NSW Health Pathology, Concord Hospital, Sydney, New South Wales, Australia.
ANZAC Research Institute, University of Sydney, Sydney, New South Wales, Australia.
Endocrinol Diabetes Metab Case Rep. 2023 Apr 12;2023(2). doi: 10.1530/EDM-22-0402. Print 2023 Apr 1.
We report the successful delivery of a healthy baby after intracytoplasmic sperm injection (ICSI) with frozen-thawed autologous sperm, cryostored for 26 years, the longest successful autologous sperm cryostorage reported. Sperm was cryostored for a 15-year-old boy at the time of his cancer diagnosis. Semen samples were frozen with cryoprotectant, using a graduated vapour-phase nitrogen protocol. Straws were stored in a large vapour-phase nitrogen tank until transfer for use. The couple underwent a single ICSI-in vitro fertilisation procedure using the frozen-thawed sperm with a transfer of five fertilised embryos, resulting in the live birth of a healthy baby boy. This reinforces the importance of offering sperm cryopreservation to men who have not completed their family prior to gonadotoxic treatment for cancer or other diseases. As practical, low-cost fertility insurance, it should be offered to any young man who can collect semen and it provides essentially unlimited duration of fertility preservation.
Gonadotoxic chemo or radiotherapy treatment for cancer or other diseases usually causes temporary or permanent male infertility. Sperm cryostorage serves as a practical, low-cost insurance to facilitate future paternity. All men who have not completed their families and are scheduled for gonadotoxic treatments should be offered sperm cryostorage. There is no lower age limit for young men who can collect semen. Sperm cryostorage offers essentially indefinite duration for the preservation of male fertility.
我们报告了一例通过胞浆内单精子注射（ICSI）成功分娩健康婴儿的案例，所用精子为冷冻解冻后的自体精子，已冷冻保存26年，这是有报道以来最长时间成功自体精子冷冻保存的案例。精子是在一名15岁男孩被诊断出患有癌症时进行冷冻保存的。精液样本使用梯度气相氮方案，与冷冻保护剂一起冷冻。麦管保存在一个大型气相氮罐中，直至转移使用。这对夫妇采用冷冻解冻后的精子进行了一次ICSI体外受精程序，并移植了5个受精卵，最终成功诞下一名健康男婴。这强化了对于那些在因癌症或其他疾病接受性腺毒性治疗前尚未完成生育的男性提供精子冷冻保存的重要性。作为一种实用、低成本的生育保险，应该为任何能够采集精液的年轻男性提供，并且它能提供基本无限期的生育力保存。
针对癌症或其他疾病的性腺毒性化疗或放疗通常会导致男性暂时或永久性不育。精子冷冻保存是一种实用、低成本的保险措施，有助于未来生育。所有尚未完成生育且计划接受性腺毒性治疗的男性都应提供精子冷冻保存。能够采集精液的年轻男性没有年龄下限。精子冷冻保存为男性生育力保存提供了基本无限期的时间。
