School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, PR China.
Chem Biol Interact. 2023 Jun 1;378:110483. doi: 10.1016/j.cbi.2023.110483. Epub 2023 Apr 10.
Selenium nanoparticles (SeNPs) are a unique type of nano-sized elemental selenium that have recently found wide application in biomedicine. It has been shown that the properties of SeNPs can be varied by different fabrication methods. Moreover, SeNPs have various therapeutic effects in medical applications due to their excellent biological and adaptable physical properties. At the same time, SeNPs can be used as a carrier medium for various therapeutic substances, which can bring out the full curative effects of the drugs. In this review, the differences in bioactivity properties of SeNPs prepared from different substances were reviewed; the therapeutic effects and mechanisms of SeNPs in cancer, inflammation, neurodegenerative diseases, diabetes, reproductive diseases, cardiovascular diseases, and other diseases were discussed; and the importance of the development of SeNPs was further emphasized.
硒纳米粒子（SeNPs）是一种独特的纳米级元素硒，最近在生物医学领域得到了广泛应用。研究表明，通过不同的制备方法可以改变 SeNPs 的性质。此外，由于其具有优异的生物适应性物理特性，SeNPs 在医学应用中具有多种治疗效果。同时，SeNPs 可以用作各种治疗物质的载体介质，从而发挥药物的全部疗效。在本综述中，我们回顾了不同物质制备的 SeNPs 的生物活性特性差异；讨论了 SeNPs 在癌症、炎症、神经退行性疾病、糖尿病、生殖疾病、心血管疾病等疾病中的治疗效果和作用机制；并进一步强调了 SeNPs 的发展重要性。
