Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, GRB-425, Boston, MA 02114, USA. Electronic address: https://twitter.com/NikhilPanda_MD.
Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, 55 Fruit Street, Austen 7, Boston, MA, 02114, USA.
Thorac Surg Clin. 2023 May;33(2):209-213. doi: 10.1016/j.thorsurg.2023.01.002. Epub 2023 Feb 26.
Following the results of the CheckMate 577 trial, the Food and Drug Administration approved adjuvant immune checkpoint inhibitor therapy for patients with locally advanced esophageal cancer without a pathologic complete response following neoadjuvant chemoradiotherapy and esophagectomy. This innovation in systemic therapy has rekindled the debate around the clinical value of an extended lymphadenectomy at the time of esophagectomy. In this article, we provide a review of the oncologic principles and potential risks and benefits of extended lymphadenectomy at the time of esophagectomy with acknowledgments to current and forthcoming innovations in thoracic surgery.
继 CheckMate 577 试验的结果之后，美国食品和药物管理局批准了辅助免疫检查点抑制剂治疗用于新辅助放化疗和食管切除术后局部晚期食管癌患者，这些患者未出现病理完全缓解。这一系统治疗的创新重新引发了关于食管切除术中扩大淋巴结清扫术的临床价值的争论。在本文中，我们回顾了胸外科当前和即将出现的创新技术背景下，食管切除术中扩大淋巴结清扫术的肿瘤学原则以及潜在风险和获益。
