Translational Research Centre in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, 690090 Vladivostok, Russia; College of Materials and Chemical Engineering, Minjiang University, Fuzhou, Fujian 350108, China.
Translational Research Centre in Oncohaematology, Department of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, CH-1211 Geneva, Switzerland; Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, 4 Akademika Oparina Str., Moscow 117997, Russia.
Trends Mol Med. 2023 Jun;29(6):468-480. doi: 10.1016/j.molmed.2023.03.006. Epub 2023 Apr 10.
Wnt signaling plays numerous functions in cancer, from primary transformation and tumor growth to metastasis. In addition to these cancer cell-intrinsic functions, Wnt signaling emerges to critically control cross-communication among cancer cells and the tumor microenvironment (TME). Here, we summarize the evidence that not only multiple cancer cell types, but also cells constituting the TME 'speak the Wnt language'. Fibroblasts, macrophages, endothelia, and lymphocytes all use the Wnt language to convey messages to and from cancer cells and among themselves; these messages are important for tumor progression and fate. Decoding this language will advance our understanding of tumor biology and unveil novel therapeutic avenues.
Wnt 信号通路在癌症中发挥着多种功能，从原发性转化和肿瘤生长到转移。除了这些癌细胞内在的功能外，Wnt 信号通路还被认为可以关键地控制癌细胞与肿瘤微环境（TME）之间的交叉通讯。在这里，我们总结了证据，表明不仅多种癌细胞类型，而且构成 TME 的细胞“使用 Wnt 语言”进行交流。成纤维细胞、巨噬细胞、内皮细胞和淋巴细胞都使用 Wnt 语言在癌细胞之间以及彼此之间传递信息；这些信息对于肿瘤的进展和命运至关重要。破译这种语言将增进我们对肿瘤生物学的理解，并揭示新的治疗途径。
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