Faculdade de Ciências da Universidade de Lisboa (FCUL-UL), Lisbon, Portugal.
CEDOC, Chronic Diseases Research Centre, NOVA Medical School | Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal.
Adv Exp Med Biol. 2020;1219:189-202. doi: 10.1007/978-3-030-34025-4_10.
The Wnt signaling pathways are well known for having several pivotal roles during embryonic development. However, the same developmental signaling pathways also present key roles in cancer initiation and progression. In this chapter, several issues regarding the roles of both canonical and non-canonical Wnt signaling pathways in cancer will be explored, mainly concerning their role in the maintenance of cancer stemness, in the metabolism reprograming of cancer cells and in the modulation of the tumor microenvironment. The role of Wnt signaling cascades in the response of cancer cells to anti-cancer treatments will be also discussed, as well as its potential therapeutic targeting during cancer treatment. Collectively, increasing evidence has been supporting pivotal roles of Wnt signaling in several features of cancer biology, however; a lot is still to be elucidated.
Wnt 信号通路在胚胎发育过程中具有多种关键作用，这是众所周知的。然而，同样的发育信号通路在癌症的发生和发展中也起着关键作用。在本章中，将探讨经典和非经典 Wnt 信号通路在癌症中的几个问题，主要涉及它们在维持癌症干细胞特性、癌细胞代谢重编程以及肿瘤微环境调节中的作用。还将讨论 Wnt 信号级联在癌细胞对癌症治疗的反应中的作用，以及在癌症治疗中对其进行潜在治疗靶向的可能性。总的来说，越来越多的证据支持 Wnt 信号在癌症生物学的几个方面起着关键作用，然而，仍有许多问题有待阐明。
