丹麦家族性结肠息肉病的发病率和患病率。

The incidence and prevalence of familial polyposis coli in Denmark.

作者信息

Bülow S, Holm N V, Hauge M

出版信息

Scand J Soc Med. 1986;14(2):67-74. doi: 10.1177/140349488601400205.

Abstract

Based on the Danish Polyposis Register, the frequency of familial polyposis coli was estimated at the end of 1982. The mean annual incidence rate of polyposis coli has remained rather constant at approximately 1 X 10(-6) X yr-1 since the forties. The life-time risk of developing polyposis coli is about 1 X 10(-4). The point prevalence rate was 26 X 10(-6) at the end of 1982. The number of cases found in sibs and children of probands made it probable that a nation-wide prophylactic examination of first degree relatives resulted in a complete identification of affected family members. The completeness of the Danish Polyposis Register in the period 1976-82 was estimated to be 90% and the validity of the diagnosis is considered to be 100%.

摘要

根据丹麦息肉病登记处的数据，1982年底对家族性结肠息肉病的发病率进行了估算。自40年代以来，结肠息肉病的年平均发病率一直相当稳定，约为1×10⁻⁶/年。患结肠息肉病的终生风险约为1×10⁻⁴。1982年底的点患病率为26×10⁻⁶。在先证者的兄弟姐妹和子女中发现的病例数表明，对一级亲属进行全国性的预防性检查有可能完全识别出受影响的家庭成员。据估计，1976 - 1982年期间丹麦息肉病登记处的完整性为90%，诊断的有效性被认为是100%。