Bülow S, Alm T, Fausa O, Hultcrantz R, Järvinen H, Vasen H
Danish Polyposis Register, Hvidovre Hospital, Copenhagen.
Int J Colorectal Dis. 1995;10(1):43-6. doi: 10.1007/BF00337586.
In order to evaluate the prevalence of duodenal adenomas in familial adenomatous polyposis (FAP) and the risk of carcinoma development, a multicenter study was initiated in Denmark, Finland, Holland, Norway and Sweden, which have national polyposis registers with an almost complete registration. Patients aged 20 years or more are being examined with biennial gastroduodenoscopy during 1990-2000. Multiple duodenal biopsies are examined by one pathologist from each country, and the endoscopic and histological criteria of Spigelman have been adopted. At the end of August 1992, 312 patients with a median age of 37 years (range 20-86) had completed their first endoscopy. The duodenum was examined in 310 patients, of whom 199 (64%) had duodenal adenomas. Twenty-two patients (11% of all patients with duodenal adenomas) had no endoscopically visible polyps. One patient had an asymptomatic adenocarcinoma. The Spigelman stage worsened significantly (P < 0.05) with time from the diagnosis of FAP, which may suggest an increasing risk of carcinoma by time.
为了评估家族性腺瘤性息肉病（FAP）患者十二指肠腺瘤的患病率以及癌变风险，丹麦、芬兰、荷兰、挪威和瑞典发起了一项多中心研究，这些国家拥有几乎完整登记信息的息肉病登记处。1990 - 2000年期间，对20岁及以上的患者每两年进行一次胃十二指肠镜检查。每个国家的一名病理学家对多个十二指肠活检样本进行检查，并采用了斯皮格尔曼的内镜和组织学标准。1992年8月底，312例中位年龄为37岁（范围20 - 86岁）的患者完成了首次内镜检查。对310例患者的十二指肠进行了检查，其中199例（64%）患有十二指肠腺瘤。22例患者（占所有十二指肠腺瘤患者的11%）没有内镜可见的息肉。1例患者患有无症状腺癌。自FAP诊断起，斯皮格尔曼分期随时间显著恶化（P < 0.05），这可能表明随着时间推移癌变风险增加。
