Bülow S, Holm N V, Mellemgaard A
Danish Polyposis Register, Department of Surgical Gastroenterology, Bispebjerg Hospital, Copenhagen.
Int J Colorectal Dis. 1988 Mar;3(1):29-31. doi: 10.1007/BF01649679.
All patients from the nationwide Danish Polyposis Register have been followed up with regard to thyroid carcinoma. During the period 1943-1985, 2/107 Danish women and 0/138 men developed papillary thyroid carcinoma after the diagnosis of familial adenomatous polyposis. The expected number among females was 0.02 resulting in a observed/expected ratio of 100 (95% confidence limits 12-361). Consequently, thyroid carcinoma should be included among the extracolonic lesions, which may develop in any female polyposis patient. However, regular thyroid examination is not indicated, as thyroid carcinoma is uncommon and as the prognosis is excellent.
丹麦全国息肉病登记处的所有患者均已就甲状腺癌进行了随访。在1943年至1985年期间，107名丹麦女性中有2名、138名男性中有0名在诊断为家族性腺瘤性息肉病后发生了乳头状甲状腺癌。女性的预期发病数为0.02，观察/预期比值为100（95%置信区间12-361）。因此，甲状腺癌应被纳入可能在任何女性息肉病患者中发生的结肠外病变之列。然而，由于甲状腺癌并不常见且预后良好，所以不建议进行常规甲状腺检查。
