Quigley G J, Ughetto G, van der Marel G A, van Boom J H, Wang A H, Rich A
Science. 1986 Jun 6;232(4755):1255-8. doi: 10.1126/science.3704650.
The structure of a DNA octamer d(GCGTACGC) cocrystallized with the bisintercalator antibiotic triostin A has been solved. The DNA forms an unwound right-handed double helix. Four base pairs are of the Watson-Crick type while four are Hoogsteen base pairs, including two A.T and two G.C base pairs. This is the first observation in an oligonucleotide of Hoogsteen G.C base pairs where the cystosine is protonated. It is likely that these also occur in solutions of DNA complexed to this antibiotic.
已解析与双嵌入剂抗生素三曲菌素 A 共结晶的 DNA 八聚体 d(GCGTACGC) 的结构。该 DNA 形成一个解旋的右手双螺旋。其中四个碱基对是沃森-克里克型，而另外四个是霍格施泰因碱基对，包括两个 A.T 和两个 G.C 碱基对。这是在寡核苷酸中首次观察到胞嘧啶质子化的霍格施泰因 G.C 碱基对。在与这种抗生素复合的 DNA 溶液中可能也会出现这些碱基对。
