Fukasawa Takemichi, Enomoto Atsushi, Yoshizaki-Ogawa Asako, Sato Shinichi, Miyagawa Kiyoshi, Yoshizaki Ayumi
Department of Dermatology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Laboratory of Molecular Radiology, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
Cancers (Basel). 2023 Mar 30;15(7):2054. doi: 10.3390/cancers15072054.
Protein kinases, found in the nucleus and cytoplasm, play essential roles in a multitude of cellular processes, including cell division, proliferation, apoptosis, and signal transduction. STK38 is a member of the protein kinase A (PKA)/PKG/PKC family implicated in regulating cell division and morphogenesis in yeast and . However, its function remained largely unknown in mammals. In recent years, advances in research on STK38 and the identification of its substrates has led to a better understanding of its function and role in mammals. This review discusses the structure, expression, and regulation of activity as a kinase, its role in the DNA damage response, cross-talk with other signaling pathways, and its application for radio-sensitization.
蛋白激酶存在于细胞核和细胞质中,在众多细胞过程中发挥着重要作用,包括细胞分裂、增殖、凋亡和信号转导。STK38是蛋白激酶A(PKA)/蛋白激酶G(PKG)/蛋白激酶C(PKC)家族的成员,与酵母中的细胞分裂和形态发生调节有关。然而,其在哺乳动物中的功能在很大程度上仍不清楚。近年来,STK38的研究进展及其底物的鉴定使人们对其在哺乳动物中的功能和作用有了更好的理解。本文综述了其作为激酶的结构、表达和活性调节、在DNA损伤反应中的作用、与其他信号通路的相互作用以及其在放射增敏中的应用。