Department of Urology, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China.
Central Laboratory, Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen 361101, China.
Int J Mol Sci. 2022 Sep 30;23(19):11590. doi: 10.3390/ijms231911590.
Although (serine-threonine kinase 38) has been proven to play an important role in cancer initiation and progression based on a series of cell and animal experiments, no systemic assessment of across human cancers is available. We firstly performed a pan-cancer analysis of in this study. The expression level of was significantly different between tumor and normal tissues in 15 types of cancers. Meanwhile, a prognosis analysis showed that a distinct relationship existed between expression and the clinical prognosis of cancer patients. Furthermore, the expression of was related to the infiltration of immune cells, such as NK cells, memory CD4+ T cells, mast cells and cancer-associated fibroblasts in a few cancers. There were three immune-associated signaling pathways involved in KEGG analysis of . In general, shows a significant prognostic value in different cancers and is closely associated with cancer immunity.
尽管（丝氨酸-苏氨酸激酶 38）已被一系列细胞和动物实验证明在癌症的发生和发展中发挥着重要作用，但目前还没有针对人类癌症的系统评估。我们首先在这项研究中对 进行了泛癌症分析。在 15 种癌症中， 的表达水平在肿瘤组织和正常组织之间有显著差异。同时，预后分析表明， 的表达与癌症患者的临床预后存在明显关系。此外，在一些癌症中， 的表达与免疫细胞的浸润有关，如 NK 细胞、记忆 CD4+T 细胞、肥大细胞和癌相关成纤维细胞。KEGG 分析显示，有三个与免疫相关的信号通路涉及 。总的来说， 在不同的癌症中表现出显著的预后价值，并且与癌症免疫密切相关。
