Talapatra Jyotirmayee, Reddy Mamatha M
The Operation Eyesight Universal Institute for Eye Cancer, L V Prasad Eye Institute, Bhubaneswar 751024, India.
School of Biotechnology, KIIT Deemed to Be University, Bhubaneswar 751024, India.
Cancers (Basel). 2023 Apr 4;15(7):2144. doi: 10.3390/cancers15072144.
Tumor cells reprogram their metabolism, including glucose, glutamine, nucleotide, lipid, and amino acids to meet their enhanced energy demands, redox balance, and requirement of biosynthetic substrates for uncontrolled cell proliferation. Altered lipid metabolism in cancer provides lipids for rapid membrane biogenesis, generates the energy required for unrestricted cell proliferation, and some of the lipids act as signaling pathway mediators. In this review, we focus on the role of lipid metabolism in embryonal neoplasms with MYCN dysregulation. We specifically review lipid metabolic reactions in neuroblastoma, retinoblastoma, medulloblastoma, Wilms tumor, and rhabdomyosarcoma and the possibility of targeting lipid metabolism. Additionally, the regulation of lipid metabolism by the MYCN oncogene is discussed.
肿瘤细胞会重新编程其代谢，包括葡萄糖、谷氨酰胺、核苷酸、脂质和氨基酸代谢，以满足其增加的能量需求、氧化还原平衡以及不受控制的细胞增殖对生物合成底物的需求。癌症中改变的脂质代谢为快速的膜生物发生提供脂质，产生不受限制的细胞增殖所需的能量，并且一些脂质充当信号通路介质。在本综述中，我们聚焦于脂质代谢在伴有MYCN失调的胚胎性肿瘤中的作用。我们特别综述神经母细胞瘤、视网膜母细胞瘤、髓母细胞瘤、肾母细胞瘤和横纹肌肉瘤中的脂质代谢反应以及靶向脂质代谢的可能性。此外，还讨论了MYCN癌基因对脂质代谢的调控。
