French National Institute of Health and Medical Research (INSERM), US14-Orphanet, 75014 Paris, France.
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Al-Neelain University, Khartoum 11121, Sudan.
Int J Mol Sci. 2023 Mar 27;24(7):6282. doi: 10.3390/ijms24076282.
The oxytocin system is well-known for its role in social bonding and reproduction. Recently, the oxytocin system was found to play other metabolic roles such as regulation of food intake, peripheral glucose uptake, and insulin sensitivity. Variants in gene have been associated with overeating, increased cardiovascular risk, and type 2 diabetes (T2D). We tested 20 microarray-derived single nucleotide polymorphisms in the gene in 212 Italian families with rich family history for T2D and found four novel and one previously reported variant suggestively significant for linkage and association with the risk of T2D. Our study has shed some light into the genetics of susceptibility to T2D at least in Italian families.
催产素系统以其在社交联系和生殖方面的作用而闻名。最近，人们发现催产素系统还具有其他代谢作用，如调节食物摄入、外周葡萄糖摄取和胰岛素敏感性。基因中的变异与暴饮暴食、心血管风险增加和 2 型糖尿病（T2D）有关。我们在 212 个具有丰富 2 型糖尿病家族史的意大利家庭中测试了 20 个微阵列衍生的单核苷酸多态性，发现了四个新的和一个以前报道的变异体，它们与 T2D 的风险有显著的连锁和关联。我们的研究至少在意大利家庭中揭示了 2 型糖尿病易感性的遗传基础。
