Biomedical Gerontology Program of the School of Medicine, Pontifical Catholic University of Rio Grande do Sul (IGG-PUCRS), Porto Alegre/RS, Brazil.
Labvitrus, Porto Alegre, RS, Brazil.
Arch Gerontol Geriatr. 2019 Sep-Oct;84:103903. doi: 10.1016/j.archger.2019.103903. Epub 2019 Jul 3.
Morbidity and mortality from cardiovascular disease is a typical phenomenon in the elderly, and are related to unfavorable genetic, hormonal and environmental (lifestyle) interactions. In this context, oxytocin (OT) seems plays a key role in the development of CVD by performing important actions in metabolism energy and hemodynamic variables.
To verify if there is an association between (OT) levels and the oxytocin receptor gene (OXTR) polymorphism (rs2254298) with cardiovascular risk factors (CRF) in the elderly.
This was a cross-sectional study in community-dwelling elderly attending primary health care. The genotyping was done using the polymerase chain reaction technique. The CRF factors investigated included hypertension, diabetes mellitus, dyslipidemia, sedentary lifestyle, and obesity. Levels of triglycerides (TGC) postprandial and glucose were measured in capillary blood. OT and cortisol levels were measured by enzyme-linked immunosorbent assay (ELISA).
The sample comprised 177 elderly individuals. OT levels showed a significant negative correlation with postprandial triglycerides (p = 0.030) and BMI (p = 0.019). OT levels were also associated with leanness (p = 0.005). On Poisson regression analysis, OT remained a predictor for leanness (p = 0.010). No significant associations were observed between the OXTR polymorphism and CRF.
The results suggest that Postprandial TGC levels are increased, while OT levels are decreased, and this hormone was significantly elevated in lean elderly. Future studies are needed to confirm these findings, and the role of OT in metabolic parameters.
心血管疾病的发病率和死亡率是老年人的典型现象，与不利的遗传、激素和环境（生活方式）相互作用有关。在这种情况下，催产素（OT）似乎通过在代谢能量和血液动力学变量中发挥重要作用，在心血管疾病（CVD）的发展中发挥关键作用。
验证 OT 水平与催产素受体基因（OXTR）多态性（rs2254298）与老年人心血管危险因素（CRF）之间是否存在关联。
这是一项在社区居住的老年人群中进行的横断面研究，他们接受初级保健。使用聚合酶链反应技术进行基因分型。调查的 CRF 因素包括高血压、糖尿病、血脂异常、久坐的生活方式和肥胖。在毛细血管血液中测量餐后甘油三酯（TGC）和葡萄糖水平。通过酶联免疫吸附试验（ELISA）测量 OT 和皮质醇水平。
该样本包括 177 名老年人。OT 水平与餐后甘油三酯（p=0.030）和 BMI（p=0.019）呈显著负相关。OT 水平也与消瘦有关（p=0.005）。在泊松回归分析中，OT 仍然是消瘦的预测因素（p=0.010）。OXTR 多态性与 CRF 之间没有观察到显著关联。
结果表明，餐后 TGC 水平升高，而 OT 水平降低，这种激素在瘦老年人中显著升高。需要进一步的研究来证实这些发现，并研究 OT 在代谢参数中的作用。
