Center for Biological Health Sciences, State University of Pará, Belém 66087670, Brazil.
Tropical Medicine Center, Federal University of Pará, Belém 66055240, Brazil.
Int J Environ Res Public Health. 2023 Mar 28;20(7):5281. doi: 10.3390/ijerph20075281.
The long-term laboratory aspects of the effects of coronavirus disease 2019 (COVID-19) on liver function are still not well understood. Therefore, this study aimed to evaluate the hepatic clinical laboratory profile of patients with up to 20 months of long-term COVID-19. A total of 243 patients of both sexes aged 18 years or older admitted during the acute phase of COVID-19 were included in this study. Liver function analysis was performed. Changes were identified in the mean levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (GGT), and ferritin. A ferritin level of >300 U/L was observed in the group that presented more changes in liver function markers (ALT, AST, and GGT). Age ≥ 60 years, male sex, AST level > 25 U/L, and GGT level ≥ 50 or 32 U/L were associated with an ALT level > 29 U/L. A correlation was found between ALT and AST, LDH, GGT, and ferritin. Our findings suggest that ALT and AST levels may be elevated in patients with long-term COVID-19, especially in those hospitalised during the acute phase. In addition, an ALT level > 29 U/L was associated with changes in the levels of other markers of liver injury, such as LDH, GGT, and ferritin.
目前对于 COVID-19 对肝功能的长期实验室影响还没有很好的了解。因此，本研究旨在评估长达 20 个月的长期 COVID-19 患者的肝脏临床实验室特征。本研究共纳入了 243 名年龄在 18 岁及以上的男女急性 COVID-19 患者。进行了肝功能分析。观察到丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、γ-谷氨酰转移酶（GGT）和铁蛋白的平均水平发生了变化。在肝功能标志物（ALT、AST 和 GGT）变化较大的组中观察到铁蛋白水平>300 U/L。年龄≥60 岁、男性、AST 水平>25 U/L 和 GGT 水平≥50 或 32 U/L 与 ALT 水平>29 U/L 相关。ALT 与 AST、LDH、GGT 和铁蛋白之间存在相关性。我们的研究结果表明，长期 COVID-19 患者的 ALT 和 AST 水平可能升高，尤其是在急性阶段住院的患者。此外，ALT 水平>29 U/L 与其他肝损伤标志物如 LDH、GGT 和铁蛋白水平的变化相关。
