Hoene Georg, von Hahn Nikolaus, Sievers Denise, Schuffelen Lukas, Wolfer Susanne, Goldstein Kathi, Schminke Boris, Brockmeyer Phillipp, Kauffmann Philipp
Clinic for Oral and Maxillofacial Surgery, University Medical Center Goettingen, Robert Koch-Str. 40, 37075, Goettingen, Germany.
Polyclinic for Orthodontics, University Medical Center Goettingen, Robert Koch-Str. 40, 37075, Goettingen, Germany.
Int J Dent. 2024 Apr 30;2024:4435791. doi: 10.1155/2024/4435791. eCollection 2024.
Medication-related osteonecrosis of the jaw (MRONJ) is a rare, serious, and debilitating disease of unknown cause that can be associated with significant health-related quality of life (HRQOL) impairment. Hematological disease is characterized by a nonhealing exposed jawbone in patients with a history of antiresorptive or antiangiogenic agent use without radiation exposure to the head or neck. . This prospective study over the period from May 2020 to December 2021 included a representative sample consisting of 27 patients with at least stage 2 MRONJ lesions who underwent surgical rehabilitation via oral and maxillofacial surgery at the University Medical Center Göttingen, Germany. Quality of life data were collected over a 6-month postoperative period using the Health-Related QOL (SF-12) and Oral Health-Related QOL (OHIP-14) questionnaires.
A total of 27 patients considered in the study had a total of 42 MRONJ lesions, corresponding to a mean of 1.56 necroses per patient. MRONJ lesions were downstaged in 85% of the patients. HRQOL was evaluated with the SF-12 questionnaire. Significant improvements were found in six of the eight categories (General Health ( < 0.001), Bodily Pain ( < 0.001), Mental Health ( < 0.001), Vitality ( < 0.001), Role-Emotional (=0.028), and Social Functioning (=0.031)). The OHRQOL score also improved significantly after surgical intervention ( < 0.001).
With completed surgical therapy, improvements in HRQOL and OHRQOL are measurable.
药物相关性颌骨坏死（MRONJ）是一种罕见、严重且使人衰弱的疾病，病因不明，可导致与健康相关的生活质量（HRQOL）显著受损。血液系统疾病的特征是有抗吸收或抗血管生成药物使用史且无头部或颈部放射暴露的患者出现颌骨暴露不愈合。这项前瞻性研究从2020年5月至2021年12月，纳入了一个具有代表性的样本，包括27例至少处于2期MRONJ病变的患者，他们在德国哥廷根大学医学中心接受了口腔颌面外科手术康复治疗。在术后6个月期间，使用与健康相关的生活质量（SF - 12）和与口腔健康相关的生活质量（OHIP - 14）问卷收集生活质量数据。
研究中的27例患者共有42处MRONJ病变，平均每位患者1.56处坏死。85%的患者MRONJ病变分期降低。使用SF - 12问卷评估HRQOL。在八个类别中的六个类别中发现了显著改善（总体健康（<0.001）、身体疼痛（<0.001）、心理健康（<0.001）、活力（<0.001）、角色情感（=0.028）和社会功能（=0.031））。手术干预后OHRQOL评分也显著改善（<0.001）。
通过完成手术治疗，HRQOL和OHRQOL的改善是可测量的。
