Department of Plant Pathology, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Gazipur 1706, Bangladesh.
College of Agricultural Sciences, International University of Business Agriculture and Technology, Dhaka 1230, Bangladesh.
Cells. 2023 Mar 31;12(7):1063. doi: 10.3390/cells12071063.
(Lib.) de Bary is a broad host-range fungus that infects an inclusive array of plant species and afflicts significant yield losses globally. Despite being a notorious pathogen, it has an uncomplicated life cycle consisting of either basal infection from myceliogenically germinated sclerotia or aerial infection from ascospores of carpogenically germinated sclerotia. This fungus is unique among necrotrophic pathogens in that it inevitably colonizes aging tissues to initiate an infection, where a saprophytic stage follows the pathogenic phase. The release of cell wall-degrading enzymes, oxalic acid, and effector proteins are considered critical virulence factors necessary for the effective pathogenesis of . Nevertheless, the molecular basis of pathogenesis is still imprecise and remains a topic of continuing research. Previous comprehensive sequencing of the genome has revealed new insights into its genome organization and provided a deeper comprehension of the sophisticated processes involved in its growth, development, and virulence. This review focuses on the genetic and genomic aspects of fungal biology and molecular pathogenicity to summarize current knowledge of the processes utilized by to parasitize its hosts. Understanding the molecular mechanisms regulating the infection process of will contribute to devising strategies for preventing infections caused by this destructive pathogen.
（利）贝氏菌是一种广泛宿主范围的真菌，感染包括一系列植物物种，并在全球范围内造成严重的产量损失。尽管它是一种臭名昭著的病原体，但它的生命周期很简单，包括由基生菌丝体萌发的菌核进行基础感染，或由顶生菌丝体萌发的子囊孢子进行气生感染。这种真菌在坏死型病原体中是独特的，因为它不可避免地会定殖衰老组织以引发感染，随后是腐生阶段。细胞壁降解酶、草酸和效应蛋白的释放被认为是有效发病所必需的关键毒力因子。然而，的发病机制的分子基础仍然不明确，仍是一个持续研究的课题。先前对的全基因组进行的综合测序揭示了其基因组组织的新见解，并深入了解了其生长、发育和毒力所涉及的复杂过程。这篇综述重点介绍真菌生物学和分子病理学的遗传和基因组方面，以总结关于利用其宿主的寄生过程的现有知识。了解调控感染过程的分子机制将有助于制定策略来预防这种破坏性病原体引起的感染。
