Forysenkova Anna A, Ivanova Valeria A, Fadeeva Inna V, Mamin Georgy V, Rau Julietta V
A.A. Baikov Institute of Metallurgy and Material Science, Russian Academy of Sciences, Leninsky Avenue 49, 119334 Moscow, Russia.
Phystech-School of Electronics, Photonics and Molecular Physics, Moscow Institute of Physics and Technology, Institutsky Lane 9, 141701 Dolgoprudny, Russia.
Materials (Basel). 2023 Apr 2;16(7):2832. doi: 10.3390/ma16072832.
Alginate is a natural polymer widely applied in materials science, medicine, and biotechnology. Its ability to bind metal ions in order to form insoluble gels has been comprehensively used to create capsules for cell technology, drug delivery, biomedical materials, etc. To modify and predict the properties of cross-linked alginate, knowledge about the mechanism of alginate binding with metal ions and the properties of its gels is necessary. This article presents the results obtained by proton Nuclear Magnetic Resonance Spectroscopy for alginate containing calcium and strontium (alkaline earth metal diamagnetic) ions and by Electron Paramagnetic Resonance Spectroscopy for alginate with copper (Cu) and manganese (Mn) (transition metal paramagnetic) ions. It was found that in the case of calcium (Ca) and Mn ions, their concentration does not affect their distribution in the alginate structure and the cross-linking density. In the case of strontium (Sr) and Cu ions, their number affects the number of binding sites and, accordingly, the cross-linking density. Thus, the cross-linking of alginate depends mainly on the characteristics of specific cations, while the nature of the bond (ionic or coordination type) is less important.
藻酸盐是一种天然聚合物，广泛应用于材料科学、医学和生物技术领域。其结合金属离子以形成不溶性凝胶的能力已被广泛用于制造用于细胞技术、药物递送、生物医学材料等的胶囊。为了改性和预测交联藻酸盐的性能，了解藻酸盐与金属离子的结合机制及其凝胶的性能是必要的。本文介绍了通过质子核磁共振光谱法对含钙和锶（碱土金属抗磁性）离子的藻酸盐以及通过电子顺磁共振光谱法对含铜（Cu）和锰（Mn）（过渡金属顺磁性）离子的藻酸盐所获得的结果。研究发现，对于钙（Ca）和锰离子，它们的浓度不影响其在藻酸盐结构中的分布和交联密度。对于锶（Sr）和铜离子，它们的数量会影响结合位点的数量，进而影响交联密度。因此，藻酸盐的交联主要取决于特定阳离子的特性，而键的性质（离子型或配位型）则不太重要。
