Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, China.
Department of Occupational and Environmental Health Sciences, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
Nutrients. 2023 Mar 29;15(7):1659. doi: 10.3390/nu15071659.
To explore the independent and combined effects of methylation and progesterone on impaired fasting glucose (IFG) and type 2 diabetes mellitus (T2DM), a case-control study including 901 subjects was conducted. Generalized linear models were performed to assess the independent and combined effects of methylation and progesterone on IFG or T2DM. Methylation level of cytosine-phosphoguanine (CpG) 1 in the estrogen receptor α () gene was positively related to IFG in both men (odds ratio () (95% confidence interval ()): 1.77 (1.05, 3.00)) and postmenopausal women ( (95% ): 1.82 (1.09, 3.04)), whereas the association between CpG 1 and T2DM was not significant. Positive associations of progesterone with IFG and T2DM were observed in both men ( (95% ): 2.03 (1.18, 3.49) and 3.00 (1.63, 5.52)) and postmenopausal women ( (95% ): 2.13 (1.27, 3.56) and 3.30 (1.85, 5.90)). Participants with high CpG 1 methylation plus high progesterone had an increased risk of IFG and T2DM, both in men and postmenopausal women. methylation and progesterone were positively associated with IFG, and the positive association between progesterone and T2DM was also found. Importantly, we firstly found the combined effects of methylation and progesterone on IFG and T2DM.
为了探索甲基化和孕酮对空腹血糖受损（IFG）和 2 型糖尿病（T2DM）的独立和联合作用，进行了一项包括 901 名受试者的病例对照研究。采用广义线性模型评估甲基化和孕酮对 IFG 或 T2DM 的独立和联合作用。雌激素受体 α（）基因中胞嘧啶-磷酸鸟嘌呤（CpG）1 的甲基化水平与男性（比值比（）（95%置信区间（））：1.77（1.05，3.00））和绝经后妇女（（95%：1.82（1.09，3.04））中的 IFG 呈正相关，而 CpG 1 与 T2DM 之间的关联不显著。孕酮与 IFG 和 T2DM 的正相关在男性（（95%：2.03（1.18，3.49）和 3.00（1.63，5.52））和绝经后妇女（（95%：2.13（1.27，3.56）和 3.30（1.85，5.90））中均观察到。高 CpG 1 甲基化加上高孕酮的参与者发生 IFG 和 T2DM 的风险增加，无论是在男性还是绝经后妇女中。甲基化和孕酮与 IFG 呈正相关，并且还发现了孕酮与 T2DM 之间的正相关。重要的是，我们首次发现了甲基化和孕酮对 IFG 和 T2DM 的联合作用。
