未诊断的中国农村人群中空腹血糖受损、2 型糖尿病的流行情况及相关危险因素：河南农村队列研究。

Prevalence of impaired fasting glucose, type 2 diabetes and associated risk factors in undiagnosed Chinese rural population: the Henan Rural Cohort Study.

机构信息

Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, China.

Department of Community Health and Family Medicine, SMHS, University for Development Studies, Tamale, Ghana.

出版信息

BMJ Open. 2019 Aug 5;9(8):e029628. doi: 10.1136/bmjopen-2019-029628.

DOI:10.1136/bmjopen-2019-029628

PMID:31383706

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6686996/

Abstract

OBJECTIVE

This study estimated the burden and characterised the risk factors associated with diabetes and impaired fasting glucose (IFG) in an undiagnosed rural population.

DESIGN

Data for 36 960 participants from the Henan Rural Cohort baseline with undiagnosed diabetes were analysed. X test and multivariate logistic regression analyses were performed to test for association between risk factors and diabetes and IFG.

RESULTS

Women constituted 60.30% of the study participants, mean age of participants was 55.32±12.18 years, risk factors for diabetes and IFG were prevalent (75% dyslipidaemia, 57% overweight/obese, 50% central obesity and 18% metabolic syndrome). The prevalence of diabetes and IFG was 4.19% and 7.22%, respectively. Having a metabolic syndrome (adjusted OR (aOR) 4.7, 95% CI 4.27 to 5.33), dyslipidaemia (aOR 2.76, 95% CI 2.31 to 3.21), centrally obese (aOR 2.38, 95% CI 2.11 to 2.70), being overweight/obese (aOR 1.66, 95% CI 1.45 to 1.79) and a family history of diabetes (aOR 1.50, 95% CI 1.15 to 1.92) were associated with diabetes. These factors were also associated with IFG. Intake of high salt diet (aOR 1.16, 95% CI 1.02 to 1.32) and smoking (aOR 1.22, 95% CI 1.02 to 1.47; significant in men) were also associated with diabetes. Engaging in moderate physical activity (aOR 0.94, 95% CI 0.89 to 0.98) was noted to be negatively associated with diabetes.

CONCLUSION

Diabetes and IFG remain prevalent in Chinese population with obesity and dyslipidaemia being some of the most significant predictors. Regular physical activity and consumption of fruits and vegetables may be beneficial in keeping blood glucose level low.

TRIAL REGISTRATION NUMBER

ChiCTR-OOC-15006699.

摘要

目的

本研究旨在评估未诊断的农村人群中糖尿病和空腹血糖受损（IFG）的负担，并分析其相关危险因素。

设计

对河南农村队列基线中 36960 名未被诊断为糖尿病的参与者进行数据分析。采用 X 检验和多因素 logistic 回归分析来检验危险因素与糖尿病和 IFG 之间的关联。

结果

女性占研究参与者的 60.30%，参与者的平均年龄为 55.32±12.18 岁，糖尿病和 IFG 的危险因素普遍存在（75%血脂异常、57%超重/肥胖、50%中心性肥胖和 18%代谢综合征）。糖尿病和 IFG 的患病率分别为 4.19%和 7.22%。患有代谢综合征（调整后的比值比[aOR] 4.7，95%置信区间[95%CI] 4.27 至 5.33）、血脂异常（aOR 2.76，95%CI 2.31 至 3.21）、中心性肥胖（aOR 2.38，95%CI 2.11 至 2.70）、超重/肥胖（aOR 1.66，95%CI 1.45 至 1.79）和糖尿病家族史（aOR 1.50，95%CI 1.15 至 1.92）与糖尿病相关。这些因素也与 IFG 相关。高盐饮食（aOR 1.16，95%CI 1.02 至 1.32）和吸烟（aOR 1.22，95%CI 1.02 至 1.47；仅在男性中具有统计学意义）也与糖尿病相关。适度的体力活动（aOR 0.94，95%CI 0.89 至 0.98）与糖尿病呈负相关。