全基因组关联分析饮酒与血液 DNA 甲基化：来自双胞胎研究的证据。
Genome-wide associations between alcohol consumption and blood DNA methylation: evidence from twin study.
机构信息
Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing 100191, PR China.
Department of Medical Epidemiology & Biostatistics, Karolinska Institute, 171 76 Stockholm, Sweden.
出版信息
Epigenomics. 2021 Jun;13(12):939-951. doi: 10.2217/epi-2021-0039. Epub 2021 May 17.
Abstract
Alcohol intake alters DNA methylation profiles and methylation might mediate the association between alcohol and disease, but limited number of positive CpG sites repeatedly replicated. In total, 57 monozygotic (MZ) twin pairs discordant for alcohol drinking from the Chinese National Twin Registry and 158 MZ and dizygotic twin pairs in the Swedish Adoption/Twin Study of Aging were evaluated. DNA methylation was detected using the Infinium HumanMethylation450 BeadChip. Among candidate CpG sites, cg07326074 was significantly correlated with drinking after adjusting for covariates in MZ twins in both datasets but not in the entire sample or dizygotic twins. The hypermethylation of cg07326074, located in the tumor-promoting gene , was associated with alcohol consumption.
摘要
饮酒改变 DNA 甲基化谱，甲基化可能介导酒精与疾病之间的关联，但重复复制的阳性 CpG 位点数量有限。 总共评估了来自中国国家双胞胎登记处的 57 对酒精摄入不一致的同卵（MZ）双胞胎和来自瑞典收养/双胞胎衰老研究的 158 对 MZ 和二卵（DZ）双胞胎。 使用 Infinium HumanMethylation450 BeadChip 检测 DNA 甲基化。 在候选 CpG 位点中，cg07326074 在两个数据集的 MZ 双胞胎中经过协变量调整后与饮酒显著相关，但在整个样本或二卵双胞胎中则不然。 位于促进肿瘤基因中的 cg07326074 的过度甲基化与饮酒有关。
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