Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Santiago 8380453, Chile.
Centro de Neurobiología y Fisiopatología Integrativa (CENFI), Instituto de Fisiología, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso 2360102, Chile.
Nutrients. 2023 Mar 31;15(7):1722. doi: 10.3390/nu15071722.
White adipose tissue (AT) dysfunction plays an important role in the development of cardiometabolic alterations associated with obesity. AT dysfunction is characterized by the loss of the expansion capacity of the AT, an increment in adipocyte hypertrophy, and changes in the secretion profile of adipose cells, associated with accumulation of macrophages and inflammation. Since not all people with an excess of adiposity develop comorbidities, it is necessary to find simple tools that can evidence AT dysfunction and allow the detection of those people with the potential to develop metabolic alterations. This review focuses on the current pathophysiological mechanisms of white AT dysfunction and emerging measurements to assess its functionality.
白色脂肪组织（AT）功能障碍在肥胖相关的代谢综合征的发展中起着重要作用。AT 功能障碍的特征是脂肪组织扩张能力丧失，脂肪细胞肥大增加，以及脂肪细胞分泌谱的变化，伴随着巨噬细胞的积累和炎症。由于并非所有肥胖的人都会出现合并症，因此有必要寻找简单的工具来证明 AT 功能障碍，并发现那些有发展代谢异常潜力的人。本综述重点介绍了白色 AT 功能障碍的当前病理生理机制和新兴的评估其功能的测量方法。
