Li Zhaoyi, Ye Yingyan, Lai Shanglei, Bao Jianfeng, Fu Ai
Institute of Hepatology and Epidemiology, Affiliated Hangzhou Xixi Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Hangzhou Linan District People's Hospital, Hangzhou, China.
Front Microbiol. 2025 Apr 3;16:1567339. doi: 10.3389/fmicb.2025.1567339. eCollection 2025.
Obesity has become a widespread metabolic disorder, marked by its escalating global prevalence. Puerarin, extracted from , one of the traditional homologies of medicine and food, demonstrates anti-obesity properties. Nonetheless, the mechanisms through which puerarin exerts its anti-obesity effects remain to be elucidated. This study seeks to highlight the potential application of puerarin in obesity management and to investigate the underlying mechanisms involving gut microbiota and lipid metabolism.
Different doses of puerarin were administered to the high-fat diet mice model, and the structure and composition of gut microbiota were analyzed using 16S rRNA sequencing. Q-PCR evaluated the expression of genes related to lipid metabolism.
Our findings demonstrate that puerarin treatment significantly reduces body weight and epithelial and beige fat mass. Furthermore, puerarin alters the structure and composition of gut microbiota, which is associated with metabolism. Additionally, puerarin treatment significantly upregulates gene expression, fatty acid transport protein 5 (FATP5) hormone-sensitive lipase (HSL), adipose triglyceride lipase (ATGL) in epithelial and beige adipose.
Puerarin demonstrates potential in ameliorating obesity by changing the structure and composition of gut microbiota, which enhances the transport of fatty acid and triglycerides hydrolysis within adipose tissue. This study provides a novel perspective on puerarin as a dietary supplement for obesity.
肥胖已成为一种广泛存在的代谢紊乱疾病，其全球患病率不断攀升。葛根素是从药食同源的传统植物中提取的，具有抗肥胖特性。然而，葛根素发挥抗肥胖作用的机制仍有待阐明。本研究旨在突出葛根素在肥胖管理中的潜在应用，并探究其涉及肠道微生物群和脂质代谢的潜在机制。
对高脂饮食小鼠模型给予不同剂量的葛根素，并使用16S rRNA测序分析肠道微生物群的结构和组成。通过Q-PCR评估脂质代谢相关基因的表达。
我们的研究结果表明，葛根素治疗可显著降低体重以及上皮脂肪和米色脂肪量。此外，葛根素改变了与代谢相关的肠道微生物群的结构和组成。此外，葛根素治疗显著上调上皮和米色脂肪中脂肪酸转运蛋白5（FATP5）、激素敏感性脂肪酶（HSL）、脂肪甘油三酯脂肪酶（ATGL）的基因表达。
葛根素通过改变肠道微生物群的结构和组成，增强脂肪组织内脂肪酸的转运和甘油三酯的水解，从而在改善肥胖方面显示出潜力。本研究为葛根素作为肥胖的膳食补充剂提供了新的视角。
