School of Exercise and Health, Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, Shanghai University of Sport, Shanghai 200438, China.
Department of Endocrinology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai 200090, China.
Nutrients. 2023 Apr 6;15(7):1784. doi: 10.3390/nu15071784.
Obesity is an epidemic all around the world. Weight loss interventions that are effective differ from each other with regard to various lipidomic responses. Here, we aimed to find lipidomic biomarkers that are related to beneficial changes in weight loss. We adopted an untargeted liquid chromatography with tandem mass spectrometry (LC-MS/MS) method to measure 953 lipid species for Exercise (exercise intervention cohort, N = 25), 1388 lipid species for LSG (laparoscopic sleeve gastrectomy cohort, N = 36), and 886 lipid species for Cushing (surgical removal of the ACTH-secreting pituitary adenomas cohort, N = 25). Overall, the total diacylglycerol (DG), triacylglycerol (TG), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylserine (PS), and sphingomyelin (SM) levels were associated with changes in BMI, glycated hemoglobin (HbA1c), triglyceride, and total cholesterol according to weight loss interventions. We found that 73 lipid species changed among the three weight loss interventions. We screened 13 lipid species with better predictive accuracy in diagnosing weight loss situations in either Exercise, LSG, or Cushing cohorts (AUROC > 0.7). More importantly, we identified three phosphatidylcholine (PC) lipid species, PC (14:0_18:3), PC (31:1), and PC (32:2) that were significantly associated with weight change in three studies. Our results highlight potential lipidomic biomarkers that, in the future, could be used in personalized approaches involving weight loss interventions.
肥胖是全球范围内的一种流行疾病。在各种脂质组学反应方面，有效的减肥干预措施彼此不同。在这里，我们旨在寻找与减肥有益变化相关的脂质组学生物标志物。我们采用了一种非靶向性的液相色谱串联质谱（LC-MS/MS）方法，用于测量 25 名接受运动干预的受试者（Exercise 干预队列）的 953 种脂质、36 名接受腹腔镜袖状胃切除术（laparoscopic sleeve gastrectomy，LSG）的受试者（LSG 队列）的 1388 种脂质和 25 名接受 ACTH 分泌性垂体腺瘤手术切除的受试者（Cushing 队列）的 886 种脂质。总体而言，总二酰基甘油（Diacylglycerol，DG）、三酰基甘油（Triacylglycerol，TG）、磷脂酰乙醇胺（Phosphatidylethanolamine，PE）、磷脂酰肌醇（Phosphatidylinositol，PI）、磷脂酰丝氨酸（Phosphatidylserine，PS）和鞘磷脂（Sphingomyelin，SM）水平与减肥干预措施引起的 BMI、糖化血红蛋白（Glycated hemoglobin，HbA1c）、甘油三酯和总胆固醇变化相关。我们发现，在三种减肥干预措施中，有 73 种脂质发生了变化。我们筛选出了 13 种在运动、LSG 或 Cushing 队列中在诊断减肥情况方面具有更好预测准确性的脂质，这些脂质的 AUC 大于 0.7。更重要的是，我们鉴定出了三种磷脂酰胆碱（Phosphatidylcholine，PC）脂质，即 PC（14:0_18:3）、PC（31:1）和 PC（32:2），它们与三种研究中的体重变化显著相关。我们的研究结果强调了一些潜在的脂质组学生物标志物，这些标志物在未来可能被用于涉及减肥干预的个体化方法中。
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