Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland.
Department of Immunology, Landspitali-The National University Hospital of Iceland, IS-101 Reykjavik, Iceland.
Molecules. 2023 Mar 24;28(7):2937. doi: 10.3390/molecules28072937.
Geobarrettin D (), a new bromoindole alkaloid, was isolated from the marine sponge collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including H-N HSQC, H-N HMBC spectra), as well as HRESIMS data. Geobarrettin D () is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D () decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound shows anti-inflammatory activity.
吉宝醇 D（），一种新的溴吲哚生物碱，从冰岛水域采集的海洋海绵中分离得到。其结构通过 1D 和 2D NMR（包括 H-N HSQC、H-N HMBC 谱）以及 HRESIMS 数据得到阐明。吉宝醇 D（）是一种新型的 6-溴吲哚，具有不寻常的嘌呤 herbipoline 部分。吉宝醇 D（）可减少人单核细胞来源的树突状细胞分泌促炎细胞因子 IL-12p40，而不影响抗炎细胞因子 IL-10 的分泌。因此，化合物 表现出抗炎活性。
