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附球菌属,独特生物活性代谢产物的新来源。

EPICOCCUM SP., AN EMERGING SOURCE OF UNIQUE BIOACTIVE METABOLITES.

作者信息

Fatima Nighat, Ismail Tariq, Muhammad Syed Aun, Jadoon Muniba, Ahmed Safia, Azhar Saira, Mumtaz Amara

出版信息

Acta Pol Pharm. 2016 Jan-Feb;73(1):13-21.

Abstract

Fungi are playing a vital role for producing natural products, most productive source of lead compounds in far reaching endeavor of new drug discovery. Epicoccum fungus is known for its potential to produce diverse classes of biologically active secondary metabolites. The intent of this review is to provide detailed information about biology and chemistry of Epicoccum fungus. Most of the fungus metabolites showed cytotoxic, anticancer, antimicrobial and anti-diabetic activities. The literature given encompases the details of isolation of different unusual and unique secondary metabolites, their chemical nature and biological activities find out Epicoccum spp., a potential source of lead molecules.

摘要

真菌在天然产物的生产中发挥着至关重要的作用,是新药研发这一影响深远的工作中先导化合物的最丰富来源。附球菌真菌以其产生多种具有生物活性的次生代谢产物的潜力而闻名。本综述旨在提供有关附球菌真菌生物学和化学的详细信息。大多数真菌代谢产物表现出细胞毒性、抗癌、抗菌和抗糖尿病活性。所提供的文献涵盖了不同寻常和独特的次生代谢产物的分离细节、它们的化学性质以及发现附球菌属作为潜在先导分子来源的生物活性。

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