Shaaxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
Mini Rev Med Chem. 2012 Feb;12(2):127-48. doi: 10.2174/138955712798995066.
The genus Chaetomium fungi are considered to be a rich source of novel and bioactive secondary metabolites of great importance. Up till now, a variety of more than 200 secondary metabolites belonging to diverse structural types of chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinones, chromones, depsidones, terpenoids, and steroids have been discovered. Most of these fungal metabolites exhibited antitumor, cytotoxic, antimalarial, enzyme inhibitory, antibiotic, and other activities. This review covers the extraction, structure elucidation, structural diversity, and biological activities of natural products isolated from about 30 fungi associated with marine- and terrestrial- origins, and highlights some bioactive compounds as well as their mechanisms of action and structure-activity relationships.
子囊菌属真菌被认为是新型生物活性次生代谢产物的丰富来源，具有重要意义。迄今为止，已发现 200 多种属于 chaetoglobosins、epipolythiodioxopiperazines、azaphilones、xanthones、anthraquinones、chromones、depsidones、萜类化合物和甾体化合物等多种结构类型的次生代谢产物。这些真菌代谢产物大多数具有抗肿瘤、细胞毒性、抗疟、酶抑制、抗生素等活性。本文综述了约 30 种海洋和陆地来源真菌中分离得到的天然产物的提取、结构鉴定、结构多样性和生物活性，重点介绍了一些具有生物活性的化合物及其作用机制和构效关系。
