College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea.
Gachon Pharmaceutical Research Institute, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, Republic of Korea.
Molecules. 2023 Apr 4;28(7):3227. doi: 10.3390/molecules28073227.
Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a variety of natural products and synthetic chemicals with a broad spectrum of biological and medicinal activities. Owing to their pharmaceutical applications and promising biological value, a variety of synthetic methodologies have been reported for these scaffolds. From the perspective of green and sustainable chemistry, transition-metal-free synthesis provides an alternative method for accessing several biologically active heterocycles. In this review, we summarize the recent progress achieved in the transition-metal-free synthesis of quinazolines and we cover the literature from 2015 to 2022. This aspect is present alongside the advantages, limitations, mechanistic rationalization, and future perspectives associated with the synthetic methodologies.
喹唑啉是一类含氮杂环化合物，具有广泛的生物活性和药用活性，广泛存在于各种天然产物和合成化学品中。由于其在药物方面的应用和广阔的前景，已经有多种合成方法被报道用于这些骨架的合成。从绿色和可持续化学的角度来看，无过渡金属合成提供了一种获得多种生物活性杂环的替代方法。在这篇综述中，我们总结了 2015 年至 2022 年期间无过渡金属合成喹唑啉的最新进展。同时，我们还讨论了这些合成方法的优点、局限性、机理合理化以及未来展望。
