Australia-China Joint Research Centre on Personal Health Technologies, Medical Device Research Institute, Flinders University, Adelaide, SA 5042, Australia.
Institute for NanoScale Science and Technology, College of Science and Engineering, Flinders University, Adelaide, SA 5042, Australia.
Molecules. 2023 Apr 5;28(7):3244. doi: 10.3390/molecules28073244.
Hydrogels have various promising prospects as a successful platform for detecting biomarkers, and human serum albumin (HSA) is an important biomarker in the diagnosis of kidney diseases. However, the difficult-to-control passive diffusion kinetics of hydrogels is a major factor affecting detection performance. This study focuses on using hydrogels embedded with aggregation-induced emission (AIE) fluorescent probe TC426 to detect HSA in real time. The vortex fluidic device (VFD) technology is used as a rotation strategy to control the reaction kinetics and micromixing during measurement. The results show that the introduction of VFD could significantly accelerate its fluorescence response and effectively improve the diffusion coefficient, while VFD processing could regulate passive diffusion into active diffusion, offering a new method for future sensing research.
水凝胶作为一种成功的生物标志物检测平台具有广阔的前景，人血清白蛋白（HSA）是诊断肾脏疾病的重要生物标志物。然而，水凝胶的扩散动力学难以控制，这是影响检测性能的一个主要因素。本研究专注于使用嵌入聚集诱导发射（AIE）荧光探针 TC426 的水凝胶来实时检测 HSA。涡旋流控装置（VFD）技术作为一种旋转策略用于控制测量过程中的反应动力学和微混合。结果表明，VFD 的引入可以显著加速其荧光响应，并有效地提高扩散系数，而 VFD 处理可以将被动扩散调节为主动扩散，为未来的传感研究提供了一种新方法。
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