Student Scientific Society of Department of Pediatric Hematology, Oncology and Transplantology, Medical University, 20-093 Lublin, Poland.
Independent Laboratory of Genetic Diagnostics, Medical University of Lublin, 20-093 Lublin, Poland.
Sensors (Basel). 2023 Mar 23;23(7):3369. doi: 10.3390/s23073369.
The incidence and mortality due to neoplastic diseases have shown an increasing tendency over the years. Based on GLOBOCAN 2020 published by the International Agency for Research on Cancer (IARC), leukemias are the thirteenth most commonly diagnosed cancer in the world, with 78.6% of leukemia cases diagnosed in countries with a very high or high Human Development Index (HDI). Carcinogenesis is a complex process initiated by a mutation in DNA that may be caused by chemical carcinogens present in polluted environments and human diet. The IARC has identified 122 human carcinogens, e.g., benzene, formaldehyde, pentachlorophenol, and 93 probable human carcinogens, e.g., styrene, diazinone. The aim of the following review is to present the chemical carcinogens involved or likely to be involved in the pathogenesis of leukemia and to summarize the latest reports on the possibility of detecting these compounds in the environment or food with the use of electrochemical sensors.
近年来，肿瘤疾病的发病率和死亡率呈上升趋势。根据国际癌症研究机构（IARC）发布的 GLOBOCAN 2020 数据，白血病是全球第十三种最常见的癌症，其中 78.6%的白血病病例发生在人类发展指数（HDI）非常高或高的国家。癌变是由 DNA 突变引发的复杂过程，这种突变可能是由污染环境和人类饮食中存在的化学致癌物引起的。IARC 已经确定了 122 种人类致癌物，例如苯、甲醛、五氯苯酚，以及 93 种可能的人类致癌物，例如苯乙烯、二嗪酮。以下综述的目的是介绍可能参与或可能参与白血病发病机制的化学致癌物，并总结最新报告，即在环境或食物中使用电化学传感器检测这些化合物的可能性。
