Gupta M M, Dani H M
Toxicol Lett. 1986 Feb;30(2):167-72. doi: 10.1016/0378-4274(86)90099-8.
Microsomes prepared at low 'g' force (10 000) have been used to evaluate the carcinogenicity of 25 coded and 14 noncoded compounds to validate the microsomal degranulation technique for its use as one of the tests in a battery of 5 to 6 tests. The method correctly predicted 35 compounds out of 39 randomly selected carcinogens and non-carcinogens showing a higher predictive efficiency in comparison to that achieved by using rough endoplasmic reticulum prepared at high 'g' forces (105 000 X g or above). The use of this technique is advocated on a large scale for the screening of environmental carcinogens.
以低“g”力（10000）制备的微粒体已用于评估25种编码化合物和14种未编码化合物的致癌性，以验证微粒体脱粒技术作为5至6项试验组合中的一项试验的适用性。该方法正确预测了39种随机选择的致癌物和非致癌物中的35种化合物，与使用高“g”力（105000×g或更高）制备的粗面内质网相比，具有更高的预测效率。提倡大规模使用该技术来筛选环境致癌物。
