Shi Liping, Zeng Linxi, Huang Xin, Wang Bin, Zhang Yuli, Zhang Guoqiang
Department of Dermatology, The First Hospital of Hebei Medical University, Shijiazhuang, People's Republic of China.
Candidate Branch of National Clinical Research Center for Skin Diseases, Shijiazhuang, People's Republic of China.
Clin Cosmet Investig Dermatol. 2023 Apr 6;16:951-957. doi: 10.2147/CCID.S404860. eCollection 2023.
Acrodermatitis continua of Hallopeau (ACH) is a rare variant of pustular psoriasis that presents as a sterile pustular eruption of the periungual and subungual regions. It affects the skin and nail bed and can lead to distal phalangeal destruction as the disease progresses. ACH is an incurable disease that requires long-term maintenance therapy to prevent any complications. Because ACH is a variant of pustular psoriasis, it is commonly treated with anti-psoriatic therapies. Unfortunately, it is resistant to many available anti-psoriatic therapies, and there are no clinical guidelines for it; the treatment is therefore highly challenging. Current treatment strategies are mostly based on a few case reports and case series. In this study, we present a case of ACH in a 24-year-old man with a long history of severe skin lesions and overt onychodystrophy, successfully treated with Ustekinumab. In this patient, we observed rapid improvement in skin lesions and symptoms. Ustekinumab can considerably improve other symptoms besides plaque psoriasis. The treatment and excellent outcomes of Ustekinumab may provide clinical benefits to more patients and serve as a reference for other dermatologists.
哈洛佩au连续性肢端皮炎（ACH）是脓疱型银屑病的一种罕见变体，表现为甲周和甲下区域的无菌性脓疱疹。它会影响皮肤和甲床，随着疾病进展可导致远端指骨破坏。ACH是一种无法治愈的疾病，需要长期维持治疗以预防任何并发症。由于ACH是脓疱型银屑病的一种变体，通常采用抗银屑病疗法进行治疗。不幸的是，它对许多现有的抗银屑病疗法都有抗性，且没有针对它的临床指南；因此治疗极具挑战性。目前的治疗策略大多基于少数病例报告和病例系列。在本研究中，我们报告了一例24岁男性ACH患者，其有严重皮肤病变和明显甲营养不良的长期病史，使用司库奇尤单抗成功治疗。在该患者中，我们观察到皮肤病变和症状迅速改善。司库奇尤单抗除了能改善斑块状银屑病外，还能显著改善其他症状。司库奇尤单抗的治疗方法及出色疗效可能会为更多患者带来临床益处，并为其他皮肤科医生提供参考。
