Department of Chemical Pathology and Endocrinology, Armed Forces Institute of Pathology, National University of Medical Sciences, Rawalpindi, Pakistan.
J Pak Med Assoc. 2023 Apr;73(4):869-871. doi: 10.47391/JPMA.6887.
Serum Magnesium plays a significant role in different diabetic complications. This comparative cross sectional study was conducted to evaluate serum magnesium levels in patients with Type 2 Diabetes Mellitus (T2DM) with and without nephropathy. A total of 182 diabetic patients (91 with nephropathy and 91 without nephropathy) were included. Odds ratio were calculated and Mann Whitney U test was used to compare quantitative variables; p<0.05 was considered significant. The results showed that 64/91 (70.3%) patients with nephropathy had hypomagnesaemia as compared to 21/91 (23.07%) patients without nephropathy. The risk of hypomagnesaemia was higher in patients with nephropathy than without nephropathy (Odds ratio 2.7 vs 0.34). Median magnesium levels (1.73 mg/dl) were lower in patients with nephropathy as compared to patients without nephropathy (2.09 mg/dl), p<0.01. It is concluded that magnesium levels were significantly lower in patients with diabetic nephropathy as compared to without nephropathy.
血清镁在不同的糖尿病并发症中起着重要作用。本研究旨在评估 2 型糖尿病（T2DM）合并和不合并肾病患者的血清镁水平。共纳入 182 名糖尿病患者（91 名合并肾病，91 名无肾病）。计算比值比并使用曼-惠特尼 U 检验比较定量变量；p<0.05 为差异有统计学意义。结果显示，91 名合并肾病的患者中，64 名（70.3%）存在低镁血症，而 91 名无肾病的患者中，21 名（23.07%）存在低镁血症。与无肾病的患者相比，合并肾病的患者发生低镁血症的风险更高（比值比 2.7 比 0.34）。与无肾病的患者相比，合并肾病的患者的镁中位数水平（1.73mg/dl）较低（2.09mg/dl），p<0.01。结论是，与无肾病的患者相比，合并肾病的患者的镁水平显著降低。
