体外模型与蛋白质组学在骨关节炎研究中的应用。
In Vitro Models and Proteomics in Osteoarthritis Research.
机构信息
Orthopaedics, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
Rheumatology and Molecular Skeletal Biology, Department of Clinical Sciences Lund, Faculty of Medicine, Lund University, Lund, Sweden.
出版信息
Adv Exp Med Biol. 2023;1402:57-68. doi: 10.1007/978-3-031-25588-5_4.
This review summarizes and exemplifies the current understanding of osteoarthritis in vitro models and describes their relevance for new insights in the future of osteoarthritis research. Our friend and highly appreciated colleague, Prof. Alan Grodzinsky has contributed greatly to the understanding of joint tissue biology and cartilage biomechanics. He frequently utilizes in vitro models and cartilage explant cultures, and recent work also includes proteomics studies. This review is dedicated to honor his 75-year birthday and will focus on recent proteomic in vitro studies related to osteoarthritis, and within this topic highlight some of his contributions to the field.
这篇综述总结并举例说明了骨关节炎的体外模型的当前认识，并描述了它们对骨关节炎研究未来新见解的相关性。我们的朋友和备受尊敬的同事 Alan Grodzinsky 教授为关节组织生物学和软骨生物力学的理解做出了巨大贡献。他经常使用体外模型和软骨外植体培养，最近的工作还包括蛋白质组学研究。这篇综述是为了纪念他 75 岁生日而撰写的，将重点介绍最近与骨关节炎相关的蛋白质组学体外研究，并在这一主题中强调他在该领域的一些贡献。
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