Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.
Instituto Gulbenkian de Ciência, 2780-156 Oeiras, Portugal.
Cell Host Microbe. 2023 Apr 12;31(4):500-512. doi: 10.1016/j.chom.2023.03.015.
The enduring coexistence between the gut microbiota and the host has led to a symbiotic relationship that benefits both parties. In this complex, multispecies environment, bacteria can communicate through chemical molecules to sense and respond to the chemical, physical, and ecological properties of the surrounding environment. One of the best-studied cell-to-cell communication mechanisms is quorum sensing. Chemical signaling through quorum sensing is involved in regulating the bacterial group behaviors, often required for host colonization. However, most microbial-host interactions regulated by quorum sensing are studied in pathogens. Here, we will focus on the latest reports on the emerging studies of quorum sensing in the gut microbiota symbionts and on group behaviors adopted by these bacteria to colonize the mammalian gut. Moreover, we address the challenges and approaches to uncover molecule-mediated communication mechanisms, which will allow us to unravel the processes that drive the establishment of gut microbiota.
肠道微生物群与宿主之间持久共存，形成了一种互利共生的关系。在这个复杂的多物种环境中，细菌可以通过化学分子进行交流，以感知和响应周围环境的化学、物理和生态特性。其中研究得最好的细胞间通讯机制之一是群体感应。通过群体感应进行的化学信号传递参与调节细菌群体行为，这对于宿主定植通常是必需的。然而，群体感应调节的大多数微生物-宿主相互作用都在病原体中进行了研究。在这里，我们将重点介绍群体感应在肠道微生物群共生体中的新兴研究以及这些细菌采用的定植哺乳动物肠道的群体行为的最新报告。此外，我们还讨论了揭示分子介导的通讯机制所面临的挑战和方法，这将使我们能够揭示驱动肠道微生物群建立的过程。
