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对抗抗菌素耐药性:噬菌体疗法的循证概述

Combating antimicrobial resistance: an evidence-based overview of bacteriophage therapy.

作者信息

Au Tsz Yuen, Assavarittirong Chanika

机构信息

Center for Medical Education in English, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Postgrad Med J. 2022 Apr 4. doi: 10.1136/postmj/postgradmedj-2022-141546.

DOI:10.1136/postmj/postgradmedj-2022-141546
PMID:37055028
Abstract

Antimicrobial resistance (AMR) problems cause an enormous challenge to our world in medicine and in agriculture and many other fields. The current situation makes bacteriophage therapy an attractive therapeutic candidate. Nevertheless, very limited clinical trials on bacteriophage therapy were performed and completed as of presence. Bacteriophage therapy alludes to infecting bacteria with a virus, this often results in a bactericidal effect. The compiled studies support the feasibility of treating AMR with bacteriophage. However, the efficacy of specific bacteriophage strains and the accurate dosage have to be further studied and tested rigorously.

摘要

抗菌耐药性(AMR)问题给我们世界的医学、农业及许多其他领域带来了巨大挑战。当前的形势使噬菌体疗法成为有吸引力的治疗候选方法。然而,截至目前,关于噬菌体疗法的临床试验开展得非常有限且已完成的数量很少。噬菌体疗法是指用病毒感染细菌,这通常会产生杀菌效果。汇编的研究支持了用噬菌体治疗抗菌耐药性的可行性。然而,特定噬菌体菌株的疗效和准确剂量还必须进一步严格研究和测试。

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