Chiș Adriana Aurelia, Rus Luca Liviu, Morgovan Claudiu, Arseniu Anca Maria, Frum Adina, Vonica-Țincu Andreea Loredana, Gligor Felicia Gabriela, Mureșan Maria Lucia, Dobrea Carmen Maximiliana
Preclinical Department, Faculty of Medicine, "Lucian Blaga" University of Sibiu, 550169 Sibiu, Romania.
Biomedicines. 2022 May 12;10(5):1121. doi: 10.3390/biomedicines10051121.
Currently, the efficacy of antibiotics is severely affected by the emergence of the antimicrobial resistance phenomenon, leading to increased morbidity and mortality worldwide. Multidrug-resistant pathogens are found not only in hospital settings, but also in the community, and are considered one of the biggest public health concerns. The main mechanisms by which bacteria develop resistance to antibiotics include changes in the drug target, prevention of entering the cell, elimination through efflux pumps or inactivation of drugs. A better understanding and prediction of resistance patterns of a pathogen will lead to a better selection of active antibiotics for the treatment of multidrug-resistant infections.
目前，抗生素的疗效受到抗菌耐药现象出现的严重影响，导致全球发病率和死亡率上升。多重耐药病原体不仅在医院环境中被发现，在社区中也有发现，被认为是最大的公共卫生问题之一。细菌对抗生素产生耐药性的主要机制包括药物靶点的改变、阻止药物进入细胞、通过外排泵排出药物或使药物失活。更好地理解和预测病原体的耐药模式将有助于更好地选择活性抗生素来治疗多重耐药感染。
