Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
National Clinical Research Center for Interventional Medicine, Shanghai, 200032, China.
Obes Rev. 2023 Jul;24(7):e13567. doi: 10.1111/obr.13567. Epub 2023 Apr 13.
Maternal obesity leads to obstetric complications and a high prevalence of metabolic anomalies in the offspring. Among various contributing factors for maternal obesity-evoked health sequelae, developmental programming is considered as one of the leading culprit factors for maternal obesity-associated chronic comorbidities. Although a unified theory is still lacking to systematically address multiple unfavorable postnatal health sequelae, a cadre of etiological machineries have been put forward, including lipotoxicity, inflammation, oxidative stress, autophagy/mitophagy defect, and cell death. Hereinto, autophagy and mitophagy play an essential housekeeping role in the clearance of long-lived, damaged, and unnecessary cell components to maintain and restore cellular homeostasis. Defective autophagy/mitophagy has been reported in maternal obesity and negatively impacts fetal development and postnatal health. This review will provide an update on metabolic disorders in fetal development and postnatal health issues evoked by maternal obesity and/or intrauterine overnutrition and discuss the possible contribution of autophagy/mitophagy in metabolic diseases. Moreover, relevant mechanisms and potential therapeutic strategies will be discussed in an effort to target autophagy/mitophagy and metabolic disturbances in maternal obesity.
母亲肥胖会导致产科并发症，并使后代代谢异常的患病率升高。在导致母亲肥胖引发的健康后果的各种因素中，发育编程被认为是导致与母亲肥胖相关的慢性合并症的主要罪魁祸首之一。尽管缺乏一个统一的理论来系统地解决多种不良的产后健康后果，但已经提出了一系列病因机制，包括脂肪毒性、炎症、氧化应激、自噬/线粒体自噬缺陷和细胞死亡。其中，自噬和线粒体自噬在清除寿命长、受损和不必要的细胞成分以维持和恢复细胞内稳态方面发挥着重要的管家作用。据报道，母亲肥胖和宫内营养过剩会导致自噬/线粒体自噬功能缺陷，并对胎儿发育和产后健康产生负面影响。本综述将介绍由母亲肥胖和/或宫内营养过剩引起的胎儿发育和产后健康问题中的代谢紊乱，并讨论自噬/线粒体自噬在代谢性疾病中的可能作用。此外，还将讨论相关机制和潜在的治疗策略，以努力针对母亲肥胖中的自噬/线粒体自噬和代谢紊乱。
