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[破裂性脑动脉瘤:指征与预后]

[Ruptured Cerebral Aneurysm:Indications and Outcomes].

作者信息

Higashi Toshio

机构信息

Department of Neurosurgery, Fukuoka University Chikushi Hospital.

出版信息

No Shinkei Geka. 2023 Mar;51(2):230-238. doi: 10.11477/mf.1436204739.

DOI:10.11477/mf.1436204739
PMID:37055045
Abstract

Selection of a reliable method to offer prompt treatment and prevent rebleeding of ruptured cerebral aneurysms is necessary because rebleeding can worsen patient outcomes. Surgical interventions for ruptured cerebral aneurysms have evolved from cervical artery ligation to clipping using a surgical microscope and endovascular coil embolization. In the International Subarachnoid Aneurysm Trial, a multicenter randomized controlled trial, the incidence of poor outcomes at 1 year after treatment was 23.7% and 30.6% in the endovascular coiling and neurosurgical clipping groups, respectively, which demonstrated the superiority of endovascular coiling over neurosurgical clipping(p = 0.0019)in patients with ruptured intracranial aneurysms. Rates of survival and independence in activities of daily living at 10 years after treatment were higher in the coiling group than in the clipping group(odds ratio: 1.34; 95% confidence interval: 1.07-1.67). The Barrow Ruptured Aneurysm Trial and several meta-analyses yielded similar results, showing the superiority of endovascular coiling over neurosurgical clipping with respect to short- and long-term clinical outcomes in patients. These results have also been reflected in the guidelines. Large clinical trials have analyzed and compared the effects of these treatments. In addition, the subsequent decade has witnessed remarkable advances in medical devices and treatment techniques for cerebral aneurysms. Clinical findings and cerebral aneurysm characteristics should be carefully evaluated to select the optimal treatment strategy for patients with ruptured cerebral aneurysms.

摘要

选择一种可靠的方法来提供及时治疗并预防破裂脑动脉瘤再出血是必要的,因为再出血会使患者的预后恶化。破裂脑动脉瘤的外科干预已从颈动脉结扎发展到使用手术显微镜夹闭和血管内弹簧圈栓塞。在国际蛛网膜下腔动脉瘤试验(一项多中心随机对照试验)中,血管内栓塞组和神经外科夹闭组治疗后1年不良预后的发生率分别为23.7%和30.6%,这表明在颅内动脉瘤破裂患者中,血管内栓塞优于神经外科夹闭(p = 0.0019)。治疗后10年,栓塞组的生存率和日常生活活动独立率高于夹闭组(优势比:1.34;95%置信区间:1.07 - 1.67)。巴罗破裂动脉瘤试验和几项荟萃分析也得出了类似结果,表明在患者的短期和长期临床结局方面,血管内栓塞优于神经外科夹闭。这些结果也已反映在指南中。大型临床试验对这些治疗方法的效果进行了分析和比较。此外,在随后的十年中,脑动脉瘤的医疗设备和治疗技术取得了显著进展。对于破裂脑动脉瘤患者,应仔细评估临床发现和脑动脉瘤特征,以选择最佳治疗策略。

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