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新冠病毒感染后肾脏 AA 淀粉样变伴快速进展性肾衰竭。

Post COVID-19 AA amyloidosis of the kidneys with rapidly progressive renal failure.

机构信息

Department of Nephrology, Government Medical College, Srinagar, Jammu and Kashmir, India.

Department of Nephrology, Khyber Medical Institute Nowpora, Srinagar, Jammu and Kashmir, India.

出版信息

Prion. 2023 Dec;17(1):111-115. doi: 10.1080/19336896.2023.2201151.

Abstract

Coronavirus disease 2019 (COVID-19) pandemic has taken the world by a storm, posing a gruelling challenge to the medical fraternity globally. Besides its very high infectivityinfectivity, significant organ dysfunction occurs in critically ill COVID-19 patients, leading to severe morbidity and mortality. Pulmonary involvement is the leading cause of death in these patients to be followed by the cardiovascular involvement. Kidney involvement due to COVID-19 is becoming more discernible with AKI adversely affecting the outcome. Besides AKI, a few cases of collapsing FSGS in genetically vulnerable patients and thrombotic microangiopathies have been reported as well. We report a case of AA amyloidosis of the kidney with a rapidly progressive renal failure and congestive heart failure with preserved left ventricular functions, which complicated a moderate COVID-19 pneumonia providing some clues to a possible association of this novel virus disease with this complication, which needs to be confirmed in future studies.

摘要

2019 年冠状病毒病(COVID-19)大流行席卷全球,给全球医学界带来了严峻的挑战。除了极高的传染性之外,重症 COVID-19 患者还会出现显著的器官功能障碍,导致严重的发病率和死亡率。肺部受累是这些患者死亡的主要原因,其次是心血管受累。COVID-19 引起的肾脏受累随着急性肾损伤(AKI)的发生变得更加明显,AKI 对预后有不利影响。除 AKI 外,还有少数在遗传易感性患者中发生的塌陷性局灶节段性肾小球硬化症(collapsing FSGS)和血栓性微血管病的病例报告。我们报告了一例伴有快速进行性肾衰竭和充血性心力衰竭(保留左心室功能)的肾脏 AA 淀粉样变性病例,该病例并发中度 COVID-19 肺炎,为这种新型病毒疾病与该并发症之间可能存在的关联提供了一些线索,这需要在未来的研究中加以证实。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0de7/10114959/62268956255c/KPRN_A_2201151_F0001_OC.jpg

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