Que Yumei, Zhang Zhaowenbin, Zhang Yanxin, Li Xin, Chen Likai, Chen Peier, Ou Caiwen, Yang Chen, Chang Jiang
Joint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Joint Centre of Translational Medicine, Wenzhou Institute, University of CAS, Wenzhou, Zhejiang, 325000, China.
Bioact Mater. 2022 Jul 16;25:716-731. doi: 10.1016/j.bioactmat.2022.07.005. eCollection 2023 Jul.
Aortic aneurysm and dissection (AAD) are leading causes of death in the elderly. Recent studies have demonstrated that silicate ions can manipulate multiple cells, especially vascular-related cells. We demonstrated in this study that silicate ions as soluble form of bioactive ceramics effectively alleviated aortic aneurysm and dissection in both Ang II and β-BAPN induced AAD models. Different from the single targeting therapeutic drug approaches, the bioactive ceramic derived approach attributes to the effect of bioactive silicate ions on the inhibition of the AAD progression through regulating the local vascular microenvironment of aorta systematically in a multi-functional way. The experiments revealed that silicate ions did not only alleviate senescence and inflammation of the mouse aortic endothelial cells, enhance M2 polarization of mouse bone marrow-derived macrophages, and reduce apoptosis of mouse aortic smooth muscle cells, but also regulate their interactions. The studies further confirm that silicate ions could effectively alleviate senescence, inflammation, and cell apoptosis of aortas, accomplished with reduced aortic dilation, collagen deposition, and elastin laminae degradation. This bioactive ceramic derived therapy provides a potential new treatment strategy in attenuating AAD progression.
主动脉瘤和主动脉夹层（AAD）是老年人死亡的主要原因。最近的研究表明，硅酸根离子可以调控多种细胞，尤其是与血管相关的细胞。我们在本研究中证明，作为生物活性陶瓷可溶形式的硅酸根离子能有效缓解血管紧张素II和β-氨基丙腈（β-BAPN）诱导的AAD模型中的主动脉瘤和主动脉夹层。与单一靶向治疗药物方法不同，生物活性陶瓷衍生方法归因于生物活性硅酸根离子通过以多功能方式系统调节主动脉局部血管微环境来抑制AAD进展的作用。实验表明，硅酸根离子不仅能减轻小鼠主动脉内皮细胞的衰老和炎症，增强小鼠骨髓来源巨噬细胞的M2极化，并减少小鼠主动脉平滑肌细胞的凋亡，还能调节它们之间的相互作用。研究进一步证实，硅酸根离子可以有效减轻主动脉的衰老、炎症和细胞凋亡，同时减少主动脉扩张、胶原沉积和弹性蛋白层降解。这种生物活性陶瓷衍生疗法为减缓AAD进展提供了一种潜在的新治疗策略。
