Chen Tao, Zhang Zhaowenbin, Weng Dong, Lu LiQin, Wang XiaoYa, Xing Min, Qiu Hui, Zhao MengMeng, Shen Li, Zhou Ying, Chang Jiang, Li Hui-Ping
Department of Respiratory Medicine, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai, China.
Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, China.
Bioact Mater. 2021 Mar 10;6(10):3194-3206. doi: 10.1016/j.bioactmat.2021.02.013. eCollection 2021 Oct.
Pulmonary fibrosis (PF) is a chronic and progressively fatal disease, but clinically available therapeutic drugs are limited due to efficacy and side effects. The possible mechanism of pulmonary fibrosis includes the damage of alveolar epithelial cells II (AEC2), and activation of immune cells such as macrophages. The ions released from bioceramics have shown the activity in stimulating soft tissue derived cells such as fibroblasts, endothelia cells and epithelia cells, and regulating macrophage polarization. Therefore, this study proposes an "ion therapy" approach based on the active ions of bioceramic materials, and investigates the therapeutic effect of bioactive ions derived from calcium silicate (CS) bioceramics on mouse models of pulmonary fibrosis. We demonstrate that silicate ions significantly reduce pulmonary fibrosis by simultaneously regulating the functions of AEC2 and macrophages. This result suggests potential clinical applications of ion therapy for lung fibrosis.
肺纤维化（PF）是一种慢性且逐渐致命的疾病，但由于疗效和副作用，临床上可用的治疗药物有限。肺纤维化的可能机制包括II型肺泡上皮细胞（AEC2）的损伤以及巨噬细胞等免疫细胞的激活。生物陶瓷释放的离子已显示出刺激成纤维细胞、内皮细胞和上皮细胞等软组织衍生细胞以及调节巨噬细胞极化的活性。因此，本研究提出一种基于生物陶瓷材料活性离子的“离子疗法”方法，并研究硅酸钙（CS）生物陶瓷衍生的生物活性离子对肺纤维化小鼠模型的治疗效果。我们证明，硅酸盐离子通过同时调节AEC2和巨噬细胞的功能，显著减轻肺纤维化。这一结果表明离子疗法在肺纤维化方面具有潜在的临床应用价值。
