Diao Zhentian, Li Longkang, Zhou Huan, Yang Lei
School of Materials Science and Engineering, Hebei University of Technology, Tianjin 300131, China.
Center for Health Science and Engineering, Hebei Key Laboratory of Biomaterials and Smart Theranostics, School of Health Sciences and Biomedical Engineering, Hebei University of Technology, Tianjin 300131, China.
Regen Biomater. 2024 May 13;11:rbae053. doi: 10.1093/rb/rbae053. eCollection 2024.
Healing of chronic diabetic wounds is challenging due to complications of severe inflammatory microenvironment, bacterial infection and poor vascular formation. Herein, a novel injectable polyvinyl alcohol-hyaluronic acid-based composite hydrogel was developed, with tannic acid (TA) and silicate functionalization to fabricate an 'all-in-one' hydrogel PTKH. On one hand, after being locally injected into the wound site, the hydrogel underwent a gradual sol-gel transition , forming an adhesive and protective dressing for the wound. Manipulations of rheological characteristics, mechanical properties and swelling ability of PTKH could be performed via regulating TA and silicate content in hydrogel. On the other hand, PTKH was capable of eliminating reactive oxygen species overexpression, combating infection and generating a cell-favored microenvironment for wound healing acceleration . Subsequent animal studies demonstrated that PTKH could greatly stimulate angiogenesis and epithelization, accompanied with inflammation and infection risk reduction. Therefore, in consideration of its impressive and outcomes, this 'all-in-one' multifunctional hydrogel may hold promise for chronic diabetic wound treatment.
由于存在严重炎症微环境、细菌感染和血管生成不良等并发症，慢性糖尿病伤口的愈合具有挑战性。在此，我们开发了一种新型的基于聚乙烯醇-透明质酸的可注射复合水凝胶，通过单宁酸（TA）和硅酸盐功能化制备了一种“一体化”水凝胶PTKH。一方面，将水凝胶局部注射到伤口部位后，它会逐渐发生溶胶-凝胶转变，形成伤口的粘性和保护性敷料。通过调节水凝胶中TA和硅酸盐的含量，可以对PTKH的流变特性、机械性能和溶胀能力进行调控。另一方面，PTKH能够消除活性氧的过度表达，对抗感染，并为加速伤口愈合创造有利于细胞生长的微环境。随后的动物研究表明，PTKH可以极大地刺激血管生成和上皮形成，同时降低炎症和感染风险。因此，鉴于其令人印象深刻的效果，这种“一体化”多功能水凝胶有望用于慢性糖尿病伤口的治疗。
