Worm Margitta, Pfaar Oliver
Division of Allergy and Immunology, Department of Dermatology, Venerology and Allergology, Campus Charité Mitte, Universitätsmedizin Berlin, and.
Section of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.
Allergol Select. 2023 Mar 31;7:84-89. doi: 10.5414/ALX02390E. eCollection 2023.
Allergen immunotherapy (AIT) and vaccination against infectious agents (VIA) are treatments actively interfering with the immune system. This raises the question of whether these therapies influence each other positively and/or negatively if applied simultaneously. For AIT, it should be taken into account that the mechanisms of subcutaneous and sublingual allergen application are in principle similar, but must be assessed in respect to vaccination differently due to their different routes of allergen administration. Here, the immunological mechanisms of both AIT application forms in respect to VIA are discussed in more detail followed by a critical discussion based on the literature and considering current practice.
变应原免疫疗法（AIT）和针对感染因子的疫苗接种（VIA）是积极干预免疫系统的治疗方法。这就引发了一个问题：如果同时应用这些疗法，它们是否会相互产生积极和/或消极的影响。对于AIT，应该考虑到皮下和舌下应用变应原的机制原则上是相似的，但由于变应原给药途径不同，在与疫苗接种相关的方面必须进行不同的评估。在此，将更详细地讨论两种AIT应用形式在VIA方面的免疫机制，随后基于文献并结合当前实践进行批判性讨论。
