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一名新冠肺炎烧伤患者的血栓栓塞预防病例报告

Case Report of Thromboembolism Prophylaxis in a Burn Patient With COVID-19.

作者信息

Alfawzan Mohammed, Alhabib Asma, Alshammari Eman, Ulhaq Muhammad M, Eldali Ahmed, Alhazmi Rawan M, Alsarhani Dana K

机构信息

Plastic and Reconstructive Surgery, King Abdulaziz Medical City, Riyadh, SAU.

Plastic Surgery, National Guard Health Affairs, King Abdulaziz Medical City, Riyadh, SAU.

出版信息

Cureus. 2023 Mar 11;15(3):e36009. doi: 10.7759/cureus.36009. eCollection 2023 Mar.

DOI:10.7759/cureus.36009
PMID:37056518
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10086270/
Abstract

The recent coronavirus disease 2019 (COVID-19) pandemic has worse medical consequences, especially when affecting people with comorbidities such as diabetes, lung disease, hypertension, burn and trauma. The pathophysiology of COVID-19 infection includes thromboembolic events that were described in previous studies as a risk of venous thromboembolism (VTE). This risk is higher in burn patients, especially in the electrical type, which is generally attributed to their hypercoagulable state. This article reviews a detailed history, examination, and investigations of a 38-year-old male hospitalized burn patient with COVID-19 infection. Although on chemical thromboembolic prophylaxis, the patient developed extensive pulmonary embolism (PE) and, more interestingly, had atypical PE signs and symptoms. The present case aims to develop a special venous thromboembolism prophylaxis protocol between prophylactic and therapeutic dosages for COVID-19 burn patients.

摘要

最近的2019冠状病毒病(COVID-19)大流行产生了更严重的医学后果,尤其是在影响患有糖尿病、肺病、高血压、烧伤和创伤等合并症的人群时。COVID-19感染的病理生理学包括血栓栓塞事件,先前的研究将其描述为静脉血栓栓塞(VTE)的风险。这种风险在烧伤患者中更高,尤其是电烧伤类型,这通常归因于他们的高凝状态。本文回顾了一名38岁住院的COVID-19感染烧伤男性患者的详细病史、检查和调查情况。尽管该患者接受了化学性血栓栓塞预防治疗,但仍发生了广泛的肺栓塞(PE),更有趣的是,该患者出现了非典型的PE体征和症状。本病例旨在为COVID-19烧伤患者制定一种介于预防剂量和治疗剂量之间的特殊静脉血栓栓塞预防方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c9/10086270/13be67fb9d4c/cureus-0015-00000036009-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c9/10086270/13be67fb9d4c/cureus-0015-00000036009-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61c9/10086270/13be67fb9d4c/cureus-0015-00000036009-i01.jpg

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本文引用的文献

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Pulmonary embolism in anticoagulated burn patient: A case report.抗凝治疗的烧伤患者发生肺栓塞:一例报告。
Saudi J Anaesth. 2021 Oct-Dec;15(4):444-446. doi: 10.4103/sja.sja_131_21. Epub 2021 Sep 2.
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COVID-19 and Venous Thromboembolism in Intensive Care or Medical Ward.COVID-19 与重症监护或内科病房中的静脉血栓栓塞症。
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Venous Thromboembolism among Hospitalized Patients with COVID-19 Undergoing Thromboprophylaxis: A Systematic Review and Meta-Analysis.
接受血栓预防的COVID-19住院患者的静脉血栓栓塞:一项系统评价和荟萃分析
J Clin Med. 2020 Aug 3;9(8):2489. doi: 10.3390/jcm9082489.
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Guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19: a position paper of the Brazilian Society of Thrombosis and Hemostasis and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy.新型冠状病毒肺炎血栓栓塞并发症的诊断、预防及治疗指南:巴西血栓形成与止血学会以及巴西血液学、血液治疗与细胞治疗协会血栓形成与止血委员会的立场文件
Hematol Transfus Cell Ther. 2020 Oct-Dec;42(4):300-308. doi: 10.1016/j.htct.2020.06.001. Epub 2020 Jun 13.
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Incidence of venous thromboembolism in hospitalized patients with COVID-19.COVID-19 住院患者静脉血栓栓塞症的发生率。
J Thromb Haemost. 2020 Aug;18(8):1995-2002. doi: 10.1111/jth.14888. Epub 2020 Jul 27.
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High risk of thrombosis in patients with severe SARS-CoV-2 infection: a multicenter prospective cohort study.严重严重急性呼吸综合征冠状病毒 2 型感染患者的血栓形成风险高:一项多中心前瞻性队列研究。
Intensive Care Med. 2020 Jun;46(6):1089-1098. doi: 10.1007/s00134-020-06062-x. Epub 2020 May 4.
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