Department of Andrology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Department of Endocrinology, Changzhou Wujin Traditional Chinese Medicine Hospital, Changzhou, China.
Andrology. 2024 Jan;12(1):68-74. doi: 10.1111/andr.13442. Epub 2023 Apr 25.
Diabetes mellitus is one of the major chronic diseases, which enhances the risk of erectile dysfunction. However, the central pathological mechanisms of erectile dysfunction in diabetes mellitus patients are still unclear.
Resting-state functional magnetic resonance imaging data were acquired in 30 type-2 diabetes mellitus, 31 type-2 diabetes mellitus with erectile dysfunction patients, and 31 healthy controls. The measure of fractional amplitude of low-frequency fluctuation was calculated and compared among groups.
Differences of fractional amplitude of low-frequency fluctuation values were found in the left superior frontal gyrus (medial) and middle temporal gyrus among three groups. Compared with healthy controls group, type-2 diabetes mellitus group exhibited lower fractional amplitude of low-frequency fluctuation values in the left superior frontal gyrus (dorsolateral), anterior cingulate gyrus, calcarine fissure, and increased fractional amplitude of low-frequency fluctuation values in the left post-central gyrus. Compared with healthy controls group, erectile dysfunction with type-2 diabetes mellitus group exhibited lower fractional amplitude of low-frequency fluctuation values in the left superior frontal gyrus (medial), middle temporal gyrus, temporal middle (pole), and increased fractional amplitude of low-frequency fluctuation values in the right post-central gyrus. Compared with type-2 diabetes mellitus group, erectile dysfunction with type-2 diabetes mellitus group exhibited increased fractional amplitude of low-frequency fluctuation values in the right median cingulum gyrus and left calcarine fissure.
Erectile dysfunction with type-2 diabetes mellitus patients showed functional changes in brain regions that were closely correlated with sexual dysfunction, which suggested that altered regional brain activity might be related to the pathophysiology of erectile dysfunction with type-2 diabetes mellitus.
糖尿病是一种主要的慢性疾病，会增加勃起功能障碍的风险。然而，糖尿病患者勃起功能障碍的中心病理机制仍不清楚。
在 30 名 2 型糖尿病患者、31 名 2 型糖尿病伴勃起功能障碍患者和 31 名健康对照者中采集静息态功能磁共振成像数据。比较各组的低频振幅分数。
三组间左侧额上回（内侧）和颞中回的低频振幅分数存在差异。与健康对照组相比，2 型糖尿病组左侧额上回（背外侧）、前扣带回、楔前叶和左侧中央后回的低频振幅分数降低。与健康对照组相比，2 型糖尿病伴勃起功能障碍组左侧额上回（内侧）、颞中回、颞中（极）和右侧中央后回的低频振幅分数降低。与 2 型糖尿病组相比，2 型糖尿病伴勃起功能障碍组右侧中央扣带回和左侧楔前叶的低频振幅分数增加。
2 型糖尿病伴勃起功能障碍患者的大脑区域功能发生变化，这些区域与性功能障碍密切相关，这表明改变的区域大脑活动可能与 2 型糖尿病伴勃起功能障碍的病理生理学有关。
