Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr, Cairo 11231, Egypt.
Pathol Res Pract. 2023 May;245:154457. doi: 10.1016/j.prp.2023.154457. Epub 2023 Apr 10.
Head and neck cancers (HNCs) are a group of heterogeneous tumors formed most frequently from epithelial cells of the larynx, lips, oropharynx, nasopharynx, and mouth. Numerous epigenetic components, including miRNAs, have been demonstrated to have an impact on HNCs characteristics like progression, angiogenesis, initiation, and resistance to therapeutic interventions. The miRNAs may control the production of numerous genes linked to HNCs pathogenesis. The roles that miRNAs play in angiogenesis, invasion, metastasis, cell cycle, proliferation, and apoptosis are responsible for this impact. The miRNAs also have an impact on crucial HNCs-related mechanistic networks like the WNT/β-catenin signaling, PTEN/Akt/mTOR pathway, TGFβ, and KRAS mutations. miRNAs may affect how the HNCs respond to treatments like radiation and chemotherapy in addition to pathophysiology. This review aims to demonstrate the relationship between miRNAs and HNCs with a particular emphasis on how miRNAs impact HNCs signaling networks.
头颈部癌症（HNCs）是一组异质性肿瘤，主要由喉、唇、口咽、鼻咽和口腔的上皮细胞形成。大量的表观遗传成分，包括 microRNAs，已被证明对 HNCs 的特征如进展、血管生成、起始和对治疗干预的抵抗有影响。miRNAs 可能控制与 HNCs 发病机制相关的众多基因的产生。miRNAs 在血管生成、侵袭、转移、细胞周期、增殖和凋亡中发挥的作用导致了这种影响。miRNAs 还对关键的 HNCs 相关机制网络如 WNT/β-catenin 信号、PTEN/Akt/mTOR 途径、TGFβ 和 KRAS 突变有影响。miRNAs 可能会影响 HNCs 对放疗和化疗等治疗的反应，除了病理生理学。本综述旨在展示 miRNAs 与 HNCs 之间的关系，特别强调 miRNAs 如何影响 HNCs 的信号网络。
