Rahmani Farzad, Avan Amir, Hashemy Seyed Isaac, Hassanian Seyed Mahdi
Department of Medical Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2018 Feb;233(2):811-817. doi: 10.1002/jcp.25897. Epub 2017 May 3.
Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. In more than 90% of all CRC patients, the master oncogenic Ras-Wnt signaling axis is over-activated. MicroRNAs (miRNAs) are potential novel diagnostic and prognostic biomarkers as well as therapeutic targets for several cancers including lung, breast, gastric, and colorectal cancers. Oncogenic or tumor suppressor miRNAs modulate tumor cells proliferation, cell cycle progression, angiogenesis, invasion, and metastasis through regulating oncogenic pathways including Wnt/β-catenin signaling. This review summarizes the current knowledge about the role of Wnt/β-catenin signaling regulatory miRNAs in the pathogenesis of colorectal cancer for a better understanding and hence a better management of this disease.
结直肠癌（CRC）是全球癌症死亡的主要原因之一。在所有CRC患者中，超过90%的患者主要致癌Ras-Wnt信号轴过度激活。微小RNA（miRNA）是包括肺癌、乳腺癌、胃癌和结直肠癌在内的几种癌症潜在的新型诊断和预后生物标志物以及治疗靶点。致癌或抑癌miRNA通过调节包括Wnt/β-连环蛋白信号在内的致癌途径来调节肿瘤细胞的增殖、细胞周期进程、血管生成、侵袭和转移。本综述总结了目前关于Wnt/β-连环蛋白信号调节miRNA在结直肠癌发病机制中的作用的知识，以便更好地理解并因此更好地管理这种疾病。
